High Risk of Adrenal Insufficiency in Adults Previously Treated for Idiopathic Childhood Onset Growth Hormone Deficiency

• Published in: The journal of clinical endocrinology and metabolism 2003-12, Vol.88 (12), p.5784-5789
• Main Authors: Lange, Martin, Feldt-Rasmussen, Ulla, Svendsen, Ole Lander, Kastrup, Knud William, Juul, Anders, Müller, Jørn
• Format: Article
• Language: English
• Subjects: Adrenal Insufficiency - diagnosis; Adrenal Insufficiency - etiology; Adrenals. Adrenal axis. Renin-angiotensin system (diseases); Adult; Biological and medical sciences; Cosyntropin; Cross-Sectional Studies; Endocrinopathies; Female; Human Growth Hormone - blood; Human Growth Hormone - deficiency; Humans; Hydrocortisone - blood; Hypothalamus. Hypophysis. Epiphysis (diseases); Insulin; Insulin-Like Growth Factor I - metabolism; Male; Medical sciences; Metabolism, Inborn Errors - complications; Non tumoral diseases. Target tissue resistance. Benign neoplasms; Risk Assessment
• ISSN: 0021-972X; 1945-7197
• DOI: 10.1210/jc.2003-030529

The aim was to reevaluate a group of adults treated for idiopathic childhood onset GH deficiency (GHD) after 18 yr without GH treatment. Twenty-six (11 females) patients participated. All but two had isolated GHD. Childhood diagnosis was established by insulin tolerance test (ITT). The patients were retested with an ITT to evaluate adult GH status. In five patients, an arginine and a synacthen test were performed instead of an ITT. Eleven of 25 patients had a subnormal cortisol response to ITT or synacthen. Ten patients had a GH peak less than 3.0 μg/liter (0.5. ± 0.5 μg/liter), whereas 16 patients displayed a normal GH response (12.3 ± 10.6 μg/liter) after ITT. IGF-I values were decreased in the patients with a pathological retest as well as in patients with a normal GH response compared with controls (P < 0.005). In 26 idiopathic childhood onset GHD patients, 44% of the patients had developed adrenal insufficiency; 38.5% had persistent GHD in adulthood, using the same test in both childhood and adulthood. Patients having a normal GH test had decreased IGF-I levels, compared with controls, indicating impaired function of a seemingly normal GH axis. It is imperative that pituitary axes other than the GH axis are tested at regular intervals, even in the absence of GHD in adulthood.