TPE or not TPE? It's no longer a question

Telomere shortening limits cancer progression and might contribute to aging in humans. In yeast, genes placed near telomeres are silenced, a phenomenon known as telomere position effect (TPE). The recent demonstration that human cells exhibit TPE raises the intriguing possibility that gene expressio...

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Bibliographic Details
Published in:Trends in pharmacological sciences (Regular ed.) 2002, Vol.23 (1), p.1-4
Main Authors: Wood, Jason G, Sinclair, David A
Format: Article
Language:English
Subjects:
aging
Aging - genetics
Animals
cancer
cellular senescence
Cellular Senescence - genetics
Gene Expression Regulation
heterochromatin
Humans
Neoplasms - genetics
Telomere - genetics
telomere position effect
TPE
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Summary:Telomere shortening limits cancer progression and might contribute to aging in humans. In yeast, genes placed near telomeres are silenced, a phenomenon known as telomere position effect (TPE). The recent demonstration that human cells exhibit TPE raises the intriguing possibility that gene expression could be ‘programmed’ by telomere shortening with major implications for cellular senescence, cancer and aging. Telomere position effect raises the intriguing possibility that gene expression could be 'programmed' by telomere shortening with major implications for cellular senescence, cancer and aging.
ISSN:0165-6147
1873-3735
DOI:10.1016/S0165-6147(00)01891-5