Circulating levels of ICAM‐1, VCAM‐1, and MCP‐1 are increased in haemodialysis patients: association with inflammation, dyslipidaemia, and vascular events

Background. Increased levels of circulating adhesion molecules and chemokines have been reported in haemodialysis (HD) patients but the influence of the HD membranes on their secretion, as well as their pathophysiological implications, remains largely unknown. Methods. Circulating levels of intercel...

Full description

Saved in:
Bibliographic Details
Published in:Nephrology, dialysis, transplantation dialysis, transplantation, 2002-03, Vol.17 (3), p.435-441
Main Authors: Papayianni, Aikaterini, Alexopoulos, Efstathios, Giamalis, Panagiotis, Gionanlis, Lazaros, Belechri, Anna‐Maria, Koukoudis, Paraschos, Memmos, Dimitrios
Format: Article
Language:English
Subjects:
adhesion molecules
Adult
Aged
Aged, 80 and over
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
atherosclerosis
Biological and medical sciences
cardiovascular disease
Cardiovascular Diseases - blood
Cardiovascular Diseases - etiology
Case-Control Studies
Chemokine CCL2 - blood
chemokines
Emergency and intensive care: renal failure. Dialysis management
Female
haemodialysis
Humans
Hyperlipidemias - blood
Hyperlipidemias - etiology
Inflammation - blood
Inflammation - etiology
Intensive care medicine
Intercellular Adhesion Molecule-1 - blood
Male
Medical sciences
Middle Aged
Renal Dialysis - adverse effects
Uremia - blood
Uremia - complications
Uremia - therapy
Vascular Cell Adhesion Molecule-1 - blood
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background. Increased levels of circulating adhesion molecules and chemokines have been reported in haemodialysis (HD) patients but the influence of the HD membranes on their secretion, as well as their pathophysiological implications, remains largely unknown. Methods. Circulating levels of intercellular adhesion molecule‐1 (ICAM‐1), vascular cell adhesion molecule‐1 (VCAM‐1), and monocyte chemoattractant protein‐1 (MCP‐1) were measured by immunosorbent assay (ELISA) in 81 HD patients (45 male, mean age 57±13 years) and 35 normal subjects. All patients had been stabilized on renal replacement therapy for >3 months and were free of active infection. Thirty‐three patients (40.7%) were routinely dialysed with modified cellulose membranes and 48 patients (59.3%) were dialysed with polysulfone membranes. Blood samples were taken directly from the arteriovenous fistula immediately before and at the end of a routine HD session. Results. Pre‐dialysis levels were significantly elevated in HD patients compared with controls (ICAM‐1 515±177 vs 238±64 ng/ml, P
ISSN:0931-0509
1460-2385
DOI:10.1093/ndt/17.3.435