Poor baroreflex gain is a marker of heightened sympathetic activity post-tachycardia termination in humans

We hypothesized that sympathetic nerve activity (SNA) remains elevated after tachycardia termination in patients with low baroreflex gain (BRG), and decreased to or below baseline in patients with high BRG. In a cohort of patients who participated in a previously published study [3], BRG, SNA, blood...

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Bibliographic Details
Published in:Clinical autonomic research 2003-12, Vol.13 (6), p.443-446
Main Authors: Kowal, Robert C, Wasmund, Stephen L, Smith, Michael L, Page, Richard L, Joglar, Jose A, Hamdan, Mohamed H
Format: Article
Language:English
Subjects:
Baroreflex
Cardiac Pacing, Artificial
Cohort Studies
Hemodynamics
Humans
Sympathetic Nervous System - physiopathology
Tachycardia - physiopathology
Tachycardia - therapy
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Summary:We hypothesized that sympathetic nerve activity (SNA) remains elevated after tachycardia termination in patients with low baroreflex gain (BRG), and decreased to or below baseline in patients with high BRG. In a cohort of patients who participated in a previously published study [3], BRG, SNA, blood pressure, and central venous pressure were measured immediately after the termination of simulated tachycardia. While the hemodynamic responses following tachycardia termination were similar in both groups, SNA remained elevated in patients with low BRG compared to a decrease below baseline levels in patients with high BRG (p = 0.04). Increased sympathetic activity following tachycardia termination could be arrhythmogenic and might play a role in the genesis of recurrent ventricular arrhythmias following tachycardia termination.
ISSN:0959-9851
1619-1560
DOI:10.1007/s10286-003-0128-0