Biochemical and Genetic Markers of Iron Status and the Risk of Coronary Artery Disease: An Angiography-based Study

Iron may promote coronary atherosclerotic disease (CAD) by increasing lipid peroxidation. Studies on biochemical or genetic markers of body iron stores as risk factors for CAD have yielded conflicting results. We studied 849 individuals with a clear-cut definition of the CAD phenotype, i.e., with (C...

Full description

Saved in:
Bibliographic Details
Published in:Clinical chemistry (Baltimore, Md.) Md.), 2002-04, Vol.48 (4), p.622-628
Main Authors: Bozzini, Claudia, Girelli, Domenico, Tinazzi, Elisa, Olivieri, Oliviero, Stranieri, Chiara, Bassi, Antonella, Trabetti, Elisabetta, Faccini, Giovanni, Pignatti, Pier Franco, Corrocher, Roberto
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Biomarkers - blood
C-Reactive Protein - analysis
Cardiology. Vascular system
Coronary Disease - blood
Coronary Disease - genetics
Coronary heart disease
Female
Ferritins - blood
Heart
Hemochromatosis - genetics
Hemochromatosis Protein
Heterozygote
Histocompatibility Antigens Class I - genetics
HLA Antigens - genetics
Humans
Inflammation - blood
Iron - metabolism
Iron Deficiencies
Lipid Peroxidation
Male
Malondialdehyde - blood
Medical sciences
Membrane Proteins
Middle Aged
Mutation
Risk Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Iron may promote coronary atherosclerotic disease (CAD) by increasing lipid peroxidation. Studies on biochemical or genetic markers of body iron stores as risk factors for CAD have yielded conflicting results. We studied 849 individuals with a clear-cut definition of the CAD phenotype, i.e., with (CAD; n = 546) or without (CAD-free; n = 303) angiographically documented disease. We determined serum ferritin, as a biochemical estimate of iron stores, and the C282Y mutation in the HFE gene, i.e., the main cause of hemochromatosis in Caucasians. The relationships of ferritin with serum markers of either inflammation [C-reactive protein (CRP)] or lipid peroxidation (malondialdehyde) were also investigated. Mean ferritin concentrations were slightly higher in CAD vs CAD-free individuals, but this difference disappeared after adjusting for sex and CRP. Ferritin was significantly correlated with CRP (Spearman's test, rho = 0.129; P
ISSN:0009-9147
1530-8561
DOI:10.1093/clinchem/48.4.622