Tandem termination signals: myth or reality?

In two Escherichia coli genomes, laboratory strain K-12 and pathological strain O157:H7, tandem termination codons as a group are slightly over-represented as termination signals. Individually however, they span the range of representations, over, as expected, or under, in one or both of the strains...

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Bibliographic Details
Published in:FEBS letters 2002-03, Vol.514 (1), p.84-89
Main Authors: Major, Louise L, Edgar, Tina D, Yee Yip, Po, Isaksson, Leif A, Tate, Warren P
Format: Article
Language:English
Subjects:
Codon, Terminator
Escherichia coli - genetics
Escherichia coli translation
Protein Biosynthesis
Tandem codon
Tandem Repeat Sequences
Termination signal
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Summary:In two Escherichia coli genomes, laboratory strain K-12 and pathological strain O157:H7, tandem termination codons as a group are slightly over-represented as termination signals. Individually however, they span the range of representations, over, as expected, or under, in one or both of the strains. In vivo, tandem termination codons do not make more efficient signals. The second codon can act as a backstop where readthrough of the first has occurred, but not at the expected efficiency. UGAUGA remains an enigma, highly over-represented, but with the second UGA a relatively inefficient back up stop codon.
ISSN:0014-5793
1873-3468
DOI:10.1016/S0014-5793(02)02301-3