Biocompatibility of micro- and nano-particles in the colon. Part II

Pathological colonic tissues were investigated with an Environmental Scanning Electron Microscope technique to verify the presence of inorganic, non-biodegradable pollutants, i.e. micro- and nano-debris of exogenous origin, after debris in liver and kidney had been discovered. In all, 18 samples of...

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Bibliographic Details
Published in:Biomaterials 2004-02, Vol.25 (3), p.385-392
Main Author: Gatti, Antonietta M.
Format: Article
Language:English
Subjects:
Biocompatibility
Biocompatible Materials - pharmacology
Colon - chemistry
Colon - metabolism
Colon - pathology
Colonic Neoplasms - metabolism
Crohn Disease - metabolism
Humans
Intestinal Mucosa - pathology
Kidney - metabolism
Liver - metabolism
Microscopy, Electron, Scanning
Microspheres
Nano-particles
Nano-pathology
Nanotechnology
Silicate
Silicates - analysis
Stainless Steel - analysis
Sulfur - chemistry
Wear debris
Zirconium - analysis
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Summary:Pathological colonic tissues were investigated with an Environmental Scanning Electron Microscope technique to verify the presence of inorganic, non-biodegradable pollutants, i.e. micro- and nano-debris of exogenous origin, after debris in liver and kidney had been discovered. In all, 18 samples of colon tissues affected by cancer and Crohn's disease were evaluated and found in all the cases to contain micro- and nano-particles. Their chemistry, detected with an X-ray microprobe, indicated a heterogeneous nature, whereas the size of the particles was homogeneous. Three control samples of healthy, young, cadavers were analysed and showed the absence of debris within the normal, healthy colon mucosa. The study reveals the presence of particulate debris, generally considered as biocompatible, in pathological specimens of human colon. The findings suggest a possible link between the presence of such particles and the underlying pathology in the cases analysed.
ISSN:0142-9612
1878-5905
DOI:10.1016/S0142-9612(03)00537-4