Epstein–Barr virus‐associated T‐cell acute lymphoblastic leukaemia

Epstein–Barr virus (EBV) is frequently detected in haematological malignancies, including Burkitt's lymphomas/leukaemias, Hodgkin's diseases and non‐Hodgkin's lymphomas. However, immature T‐cell malignancies associated with EBV have not been reported previously. We report a patient wi...

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Bibliographic Details
Published in:British journal of haematology 2002-04, Vol.117 (1), p.127-129
Main Authors: Sakajiri, Sakura, Mori, Kiyoshi, Isobe, Yasushi, Kawamata, Norihiko, Oshimi, Kazuo
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Blotting, Southern
episomal form
Epstein-Barr virus
Female
Hematologic and hematopoietic diseases
Hematology
Herpesvirus 4, Human
Humans
immature T‐cell malignancy
In Situ Hybridization
Leukemia-Lymphoma, Adult T-Cell - pathology
Leukemia-Lymphoma, Adult T-Cell - virology
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Leukemic Infiltration
Liver - pathology
Medical sciences
Spleen - pathology
T‐cell acute lymphoblastic leukaemia (T‐ALL)
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Summary:Epstein–Barr virus (EBV) is frequently detected in haematological malignancies, including Burkitt's lymphomas/leukaemias, Hodgkin's diseases and non‐Hodgkin's lymphomas. However, immature T‐cell malignancies associated with EBV have not been reported previously. We report a patient with T‐cell acute lymphoblastic leukaemia (T‐ALL), whose leukaemic cells had EBV, confirmed by Southern blotting and in situ hybridization. The EBV existed in episomal form and was detected in most leukaemic cells, but not in bystander normal B‐cells. The leukaemic cells, massively infiltrated into the liver and spleen, were resistant to chemotherapy. EBV might be associated with tumorigenesis of T‐ALL, and characteristic clinical features of the patient.
ISSN:0007-1048
1365-2141
DOI:10.1046/j.1365-2141.2002.03372.x