Analysis of a phosphorylcholine-based polymer coating on a coronary stent pre- and post-implantation

There has been a move towards surface treatments for metallic coronary stents in an effort to improve their compatibility within the body and to provide a vehicle for the delivery of therapeutics. The Bio divYsio™ range of stents is characterised by a biocompatible coating comprised of a crosslinked...

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Bibliographic Details
Published in:Biomaterials 2002-04, Vol.23 (7), p.1697-1706
Main Authors: Lewis, A.L., Tolhurst, L.A., Stratford, P.W.
Format: Article
Language:English
Subjects:
Animals
Arteries - pathology
Biocompatible Materials
Coronary stent
Coronary Vessels - pathology
Crosslinkable coating
Drug delivery
Drug Delivery Systems
Endothelium - pathology
Enzyme-Linked Immunosorbent Assay
Implantation
Microscopy, Atomic Force
Microscopy, Electron, Scanning
Microscopy, Fluorescence
Phosphorylcholine
Phosphorylcholine - chemistry
Polymers - chemistry
Restenosis
Stents
Swine
Time Factors
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Summary:There has been a move towards surface treatments for metallic coronary stents in an effort to improve their compatibility within the body and to provide a vehicle for the delivery of therapeutics. The Bio divYsio™ range of stents is characterised by a biocompatible coating comprised of a crosslinked phosphorylcholine (PC)-based polymer. In addition to a review of some of the data collected to support safety and efficacy of this device, this paper also describes a number of techniques that have been employed to both visualise and quantify the coating on the stent. Explantation of both coated and uncoated stents from porcine coronary arteries revealed that both coated and uncoated stents were >90% endothelialised after 5 days. Typical histological analysis of stented vessel sections after 4 and 12 weeks implantation showed the presence of cell types characteristic of the inflammatory response associated with the trauma caused by stent placement, with no evidence for any additional coating-related adverse inflammatory sequelae. Finally, it was demonstrated by AFM and SEM that both the thickness and force required to remove the coating were essentially unchanged after 6 months implantation. Thus, both the long-term stability and relative biological inertness of the coating has been confirmed in vivo, supporting its use as a vehicle for local drug delivery.
ISSN:0142-9612
1878-5905
DOI:10.1016/S0142-9612(01)00297-6