Circulating adhesion molecules in sera of asthmatic children

Infiltration of cells into the lung in asthma is regulated by several expressions of cell adhesion molecules (CAMs) on cells present in the airways, and may play a role in the pathogenesis of bronchial asthma. We sought to evaluate the role of serum concentrations of the soluble forms of intercellul...

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Bibliographic Details
Published in:Pediatric pulmonology 2002-04, Vol.33 (4), p.249-254
Main Authors: Tang, Ren-Bin, Chen, Shu-Jen, Soong, Wen-Jue, Chung, Ruey-Lung
Format: Article
Language:English
Subjects:
Acute Disease
adhesion molecule
Adolescent
Allergic diseases
asthma
Asthma - blood
Biological and medical sciences
Child
Child, Preschool
children
E-Selectin - blood
Humans
Immunopathology
inflammation
Intercellular Adhesion Molecule-1 - blood
Medical sciences
prednisolone therapy
Respiratory and ent allergic diseases
Vascular Cell Adhesion Molecule-1 - blood
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Summary:Infiltration of cells into the lung in asthma is regulated by several expressions of cell adhesion molecules (CAMs) on cells present in the airways, and may play a role in the pathogenesis of bronchial asthma. We sought to evaluate the role of serum concentrations of the soluble forms of intercellular adhesion molecule‐1 (sICAM‐1), vascular cell adhesion molecule‐1 (sVCAM‐1), and E‐selectin (sE‐selectin) in the control of disease activity in acute asthma. Circulating levels of sICAM‐1, sVCAM‐1, and sE‐selectin in sera from 15 normal control subjects and from 20 allergic asthmatic children with acute exacerbations who had returned to stable condition were determined by using commercially available enzyme‐linked immunosorbent assay kits. The mean concentration of serum sICAM‐1 levels was significantly higher during an acute exacerbation of asthmatic children than in those with stable asthma (19.41 ± 10.65 ng/mL vs. 13.46 ± 5.44 ng/mL; P 
ISSN:8755-6863
1099-0496
DOI:10.1002/ppul.10063