Serum time course of two brain-specific proteins, alpha(1) brain globulin and neuron-specific enolase, in tick-born encephalitis and Lyme disease

• Published in: Clinica chimica acta 2002-06, Vol.320 (1-2), p.117-125
• Main Authors: Chekhonin, Vladimir P, Zhirkov, Yury A, Belyaeva, Irina A, Ryabukhin, Igor A, Gurina, Olga I, Dmitriyeva, Tatiana B
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Biomarkers - blood; Biomarkers - cerebrospinal fluid; Brain Chemistry; Encephalitis, Tick-Borne - blood; Encephalitis, Tick-Borne - cerebrospinal fluid; Encephalitis, Tick-Borne - enzymology; Globulins - analysis; Globulins - cerebrospinal fluid; Humans; Immunochemistry; Lyme Disease - blood; Lyme Disease - cerebrospinal fluid; Lyme Disease - enzymology; Middle Aged; Neurons - enzymology; Phosphopyruvate Hydratase - blood; Phosphopyruvate Hydratase - cerebrospinal fluid; Sensitivity and Specificity; Time Factors
• ISSN: 0009-8981
• DOI: 10.1016/S0009-8981(02)00057-8

Time courses of the serum concentrations of two brain-specific proteins (BSP), alpha(1) brain globulin (alpha(1)BG, an astroglial marker) and neuron-specific enolase (NSE), were studied in patients with severe tick-born encephalitis (TBE) and Lyme disease (LD; neuroborreliosis). The concentrations were determined on the second day of the acute phase and then on the 7th, 12th, 18th, and 23rd days. Apparent rate constants for the elimination of the BSP from blood (k(e)) were calculated with the non-linear regression. In patients with TBE, the highest serum concentrations of alpha(1)BG and NSE, observed on the second day, were followed by their monotonic decrease to the normal levels reached by the 23rd day. The mean k(e) values for alpha(1)BG and NSE were found to be significantly different (0.086+/-0.003 vs. 0.057+/-0.006 day(-1), respectively; p