Effects of age, race, gender, blood pressure, and estrogen on arterial compliance

Although a variety of factors have been shown to influence vascular compliance in humans, few studies have been large enough to adequately assess the effects of age, race, gender, blood pressure (BP), and estrogen therapy. As part of a long-term follow-up study, 272 subjects, 50% women, 26% African...

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Bibliographic Details
Published in:American journal of hypertension 2002-04, Vol.15 (4), p.358-363
Main Authors: Weinberger, Myron H, Fineberg, Naomi S, Fineberg, S.Edwin
Format: Article
Language:English
Subjects:
Adult
age
Age Factors
Aged
Aged, 80 and over
Arteries - drug effects
Arteries - physiology
Biological and medical sciences
Black or African American
Black People
Blood Pressure
Cardiovascular system
Compliance
estrogen
Estrogen Replacement Therapy
Estrogens - pharmacology
Female
gender
Humans
Hypertension - physiopathology
Investigative techniques of hemodynamics
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Middle Aged
pulse pressure
resistance
Sex Factors
Vascular compliance
Vascular Resistance
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Summary:Although a variety of factors have been shown to influence vascular compliance in humans, few studies have been large enough to adequately assess the effects of age, race, gender, blood pressure (BP), and estrogen therapy. As part of a long-term follow-up study, 272 subjects, 50% women, 26% African American, 71% currently hypertensive, ranging in age from 33 to 80 years were studied with noninvasive measures of vascular compliance by pulse wave analysis. A significant age-related decrease in large and small vessel compliance and increase in vascular resistance and impedance was seen in all hypertensive subjects and in normotensive women. The slope of the relationship was significantly steeper for women than for men. No effect of estrogen or race could be observed. In hypertensive subjects, pulse pressure exerted an effect similar to that of age. Studies of vascular compliance must consider a variety of demographic and physiologic factors including age, gender, and BP. Race and estrogen administration do not appear to contribute to the variables independent of the factors identified.
ISSN:0895-7061
1879-1905
1941-7225
DOI:10.1016/S0895-7061(02)02261-6