Loading…
Changes in LDL size and HDL concentration in normal and preeclamptic pregnancies
The aim of this study was to evaluate changes in lipids, apolipoproteins and lipoproteins in Portuguese pregnant women and their potential involvement in the pathophysiology of preeclampsia. A cross-sectional study was performed by collecting blood samples in the first ( n=64), second ( n=48) and th...
Saved in:
Published in: | Atherosclerosis 2002-06, Vol.162 (2), p.425-432 |
---|---|
Main Authors: | , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | The aim of this study was to evaluate changes in lipids, apolipoproteins and lipoproteins in Portuguese pregnant women and their potential involvement in the pathophysiology of preeclampsia. A cross-sectional study was performed by collecting blood samples in the first (
n=64), second (
n=48) and third (
n=67) trimesters and
puerperium (
n=32) of normal pregnancies. Samples from preeclamptic women were obtained in the third trimester (
n=51) and in
puerperium (
n=26). As normal pregnancy progressed and triglyceride (TG) levels rose there was a decrease in low density lipoprotein (LDL) size, as measured by peak and mean particle diameter (MPD), with an increased proportion of atherogenic small dense LDL. Preeclamptic women exhibited, in the third trimester and
puerperium, higher mean serum TG concentration and lower high density lipoprotein (HDL) cholesterol and apolipoprotein A-I (apo A-I) levels compared with healthy pregnant women. In the third trimester, LDL–mean particle diameter (LDL–MPD) and LDL cholesterol–apolipoprotein B (LDLc–apo B) ratio were also significantly reduced in the pathologic group. We conclude that human gestation is associated with an ‘atherogenic’ lipid profile that is further enhanced in preeclampsia and that this profile may be a potential contributor to endothelial cell dysfunction. |
---|---|
ISSN: | 0021-9150 1879-1484 |
DOI: | 10.1016/S0021-9150(01)00734-1 |