Reactive oxygen species contribute to contractile dysfunction following rapid ventricular pacing in dogs

Background: Ventricular tachyarrhythmias may produce subsequent myocardial dysfunction through the formation of oxygen-derived free radicals. We tested the hypothesis that the antioxidant N-acetylcysteine enhances recovery of contractile function after rapid ventricular pacing. Methods: Barbiturate-...

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Bibliographic Details
Published in:International journal of cardiology 2002-05, Vol.83 (2), p.125-131
Main Authors: Gare, Meir, Mraovic, Boris, Kehl, Franz, Kersten, Judy R., Warltier, David C., Pagel, Paul S.
Format: Article
Language:English
Subjects:
Acetylcysteine - pharmacology
Analysis of Variance
Animals
Biological and medical sciences
Cardiac dysrhythmias
Cardiac Pacing, Artificial
Cardiology. Vascular system
Disease Models, Animal
Dogs
Female
Free Radical Scavengers - pharmacology
Heart
Heart Function Tests
Hemodynamics - physiology
Male
Medical sciences
Myocardial contractility
Myocardial Contraction - drug effects
Myocardial Contraction - physiology
Myocardial protection
Myocardial stunning
Myocardial Stunning - physiopathology
N-Acetylcysteine
Probability
Random Allocation
Rapid ventricular pacing
Reactive Oxygen Species
Reference Values
Stroke Volume - drug effects
Ventricular Dysfunction, Left - physiopathology
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Summary:Background: Ventricular tachyarrhythmias may produce subsequent myocardial dysfunction through the formation of oxygen-derived free radicals. We tested the hypothesis that the antioxidant N-acetylcysteine enhances recovery of contractile function after rapid ventricular pacing. Methods: Barbiturate-anesthetized dogs were instrumented for measurement of systemic and coronary hemodynamics and subendocardial segment shortening (%SS). All dogs were subjected to 3 h of rapid ventricular pacing (230 beats/min) followed by a 2 h recovery period. In three groups ( n=8 each), dogs received intravenous 0.9% saline or N-acetylcysteine (50 or 150 mg/kg over 60 min) in a random manner before pacing. Results: N-acetylcysteine did not affect systemic and coronary hemodynamics or alter regional myocardial contractility. Rapid ventricular pacing significantly ( P
ISSN:0167-5273
1874-1754
DOI:10.1016/S0167-5273(02)00030-X