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Site‐specific familial aggregation of prostate cancer

Over the last decade, epidemiologic evidence has accumulated in favor of a significant but heterogeneous hereditary component in prostate cancer (PC) susceptibility. In order to map and clone PC susceptibility genes, stratification of PC families into genetically homogeneous groups appears to be a k...

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Published in:International journal of cancer 2004-04, Vol.109 (4), p.611-617
Main Authors: Verhage, Bas A.J., Aben, Katja K.H., Witjes, J. Alfred, Straatman, Huub, Schalken, Jack A., Kiemeney, Lambertus A.L.M.
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description Over the last decade, epidemiologic evidence has accumulated in favor of a significant but heterogeneous hereditary component in prostate cancer (PC) susceptibility. In order to map and clone PC susceptibility genes, stratification of PC families into genetically homogeneous groups appears to be a key issue. Subset definition based on age at diagnosis, presumed mode of inheritance, number of affecteds per family and coaggregation of PC with other cancers has already proven successful in some studies. Previously, the finding of the coaggregation of malignancies of the central nervous system within PC families helped to link a prostate‐brain cancer susceptibility gene (CAPB) to chromosome 1p36. In this study, we evaluate the risk of PC and malignancies at other sites among first‐degree relatives of a large population‐based group of Dutch PC patients. A population‐based family case‐control study was initiated that included Caucasian PC patients newly diagnosed between July 1996 and December 1999. Information on 12,575 first‐degree relatives of 704 PC patients and 1,371 controls was collected through postal questionnaires and telephone interviews. All reported PC in first‐degree relatives was verified through medical records. In our population, PC has a strong familial component that is reflected by a 2.9‐fold increased risk (95% CI = 2.2–3.9) of PC for first‐degree relatives of PC patients. This familial risk was somewhat higher among brothers (hazard ratio = 3.9; 95% CI = 2.4–6.4) compared to fathers (hazard ratio = 2.5; 95% CI = 1.7–3.6). Cancers at other sites did not coaggregate with PC. Our data suggest that familial PC, at least in this Western European population, is site‐specific, not part of an inherited cancer syndrome. © 2004 Wiley‐Liss, Inc.
doi_str_mv 10.1002/ijc.20015
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Alfred</creatorcontrib><creatorcontrib>Straatman, Huub</creatorcontrib><creatorcontrib>Schalken, Jack A.</creatorcontrib><creatorcontrib>Kiemeney, Lambertus A.L.M.</creatorcontrib><title>Site‐specific familial aggregation of prostate cancer</title><title>International journal of cancer</title><addtitle>Int J Cancer</addtitle><description>Over the last decade, epidemiologic evidence has accumulated in favor of a significant but heterogeneous hereditary component in prostate cancer (PC) susceptibility. In order to map and clone PC susceptibility genes, stratification of PC families into genetically homogeneous groups appears to be a key issue. Subset definition based on age at diagnosis, presumed mode of inheritance, number of affecteds per family and coaggregation of PC with other cancers has already proven successful in some studies. 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Urinary tract diseases</subject><subject>prostate cancer</subject><subject>Prostatic Neoplasms - diagnosis</subject><subject>Prostatic Neoplasms - epidemiology</subject><subject>Prostatic Neoplasms - genetics</subject><subject>risk factor</subject><subject>Risk Factors</subject><subject>Surveys and Questionnaires</subject><subject>Tumors of the urinary system</subject><subject>Urinary tract. 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In our population, PC has a strong familial component that is reflected by a 2.9‐fold increased risk (95% CI = 2.2–3.9) of PC for first‐degree relatives of PC patients. This familial risk was somewhat higher among brothers (hazard ratio = 3.9; 95% CI = 2.4–6.4) compared to fathers (hazard ratio = 2.5; 95% CI = 1.7–3.6). Cancers at other sites did not coaggregate with PC. Our data suggest that familial PC, at least in this Western European population, is site‐specific, not part of an inherited cancer syndrome. © 2004 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>14991584</pmid><doi>10.1002/ijc.20015</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
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subjects Aged
Biological and medical sciences
cancer
Case-Control Studies
clustering
Cohort Studies
European Continental Ancestry Group
familial aggregation
Family Health
Humans
Interviews as Topic
Male
Medical sciences
Middle Aged
Neoplasms - diagnosis
Neoplasms - epidemiology
Neoplasms - genetics
Neoplastic Syndromes, Hereditary - diagnosis
Neoplastic Syndromes, Hereditary - epidemiology
Neoplastic Syndromes, Hereditary - genetics
Nephrology. Urinary tract diseases
prostate cancer
Prostatic Neoplasms - diagnosis
Prostatic Neoplasms - epidemiology
Prostatic Neoplasms - genetics
risk factor
Risk Factors
Surveys and Questionnaires
Tumors of the urinary system
Urinary tract. Prostate gland
title Site‐specific familial aggregation of prostate cancer
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