MR perfusion imaging in proliferative angiopathy

Seizures, which may be the main expression of cerebral arteriovenous malformations (CAVM) can be difficult to control medically. Our goal was to use perfusion-weighted imaging (PWI) in correlation with clinical data to detect abnormal areas of the cerebrum related to a particular type of CAVM (proli...

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Bibliographic Details
Published in:Neuroradiology 2004-02, Vol.46 (2), p.105-112
Main Authors: DUCREUX, D, MEDER, J. F, FREDY, D, BITTOUN, J, LASJAUNIAS, P
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Blood Flow Velocity - physiology
Blood Volume - physiology
Brain Ischemia - diagnosis
Carotid Artery, Internal - abnormalities
Carotid Artery, Internal - pathology
Cerebellum - blood supply
Cerebral Cortex - blood supply
Contrast Media - administration & dosage
Deglutition Disorders - etiology
Diagnosis, Differential
Dominance, Cerebral - physiology
Embolization, Therapeutic
Epilepsy - etiology
Female
Follow-Up Studies
Fourier Analysis
Gadolinium DTPA
Humans
Image Enhancement
Image Processing, Computer-Assisted
Intracranial Arteriovenous Malformations - diagnosis
Intracranial Arteriovenous Malformations - therapy
Investigative techniques, diagnostic techniques (general aspects)
Magnetic Resonance Angiography
Male
Medical imaging
Medical sciences
Middle Aged
Nervous system
Neurology
NMR
Nuclear magnetic resonance
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Regional Blood Flow - physiology
Sensitivity and Specificity
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Summary:Seizures, which may be the main expression of cerebral arteriovenous malformations (CAVM) can be difficult to control medically. Our goal was to use perfusion-weighted imaging (PWI) in correlation with clinical data to detect abnormal areas of the cerebrum related to a particular type of CAVM (proliferative angiopathy) and to study the pathophysiology. We use PWI, with a bolus injection of contrast medium, to investigate seven patients with proliferative angiopathy and fits producing language disturbance. Perfusion parameters were calculated using the first-pass moment theory. Five patients had perimalformative and/or contralateral abnormal areas with relative hyperperfusion (cerebral blood volume +20.7+/-16.2%, blood flow 92.5+/-68.8 ml/min/100 g). Areas of hypoperfusion and venous congestion were detected in two patients. One patient who underwent MRI after a severe focal deficit had no significant haemodynamic abnormality.
ISSN:0028-3940
1432-1920
DOI:10.1007/s00234-003-1045-6