Cytokeratin expression in central mucoepidermoid carcinoma and glandular odontogenic cyst

Central mucoepidermoid carcinoma (MEC) is an entity whose origin is still controversial. Glandular odontogenic cyst (GOC) is a recently described lesion whose relationship to low-grade central MEC has been reported in the literature. Our aim was to assess the cytokeratin (CK) profile of central MEC...

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Bibliographic Details
Published in:Oral oncology 2004-05, Vol.40 (5), p.545-551
Main Authors: Pires, Fábio Ramôa, Chen, Sow-Yeh, da Cruz Perez, Danyel Elias, de Almeida, Oslei Paes, Kowalski, Luiz Paulo
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Carcinoma, Mucoepidermoid - chemistry
Carcinoma, Mucoepidermoid - pathology
Central
Cytokeratins
Female
Glandular odontogenic cyst
Humans
Immunohistochemistry - methods
Intraosseous
Jaw Diseases - metabolism
Jaw Diseases - pathology
Keratins - analysis
Male
Mandibular Diseases - metabolism
Mandibular Diseases - pathology
Maxillary Diseases - metabolism
Maxillary Diseases - pathology
Medical sciences
Middle Aged
Mucoepidermoid carcinoma
Odontogenic Cysts - chemistry
Odontogenic Cysts - pathology
Otorhinolaryngology. Stomatology
Salivary Gland Neoplasms - chemistry
Salivary Gland Neoplasms - pathology
Tumors
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Summary:Central mucoepidermoid carcinoma (MEC) is an entity whose origin is still controversial. Glandular odontogenic cyst (GOC) is a recently described lesion whose relationship to low-grade central MEC has been reported in the literature. Our aim was to assess the cytokeratin (CK) profile of central MEC and GOC, and compare the results with CK expression in salivary gland MEC and odontogenic cysts and tumors. Eighty-five cases, including 6 central MECs, 23 salivary gland MECs, 10 GOCs, 34 odontogenic cysts and 12 ameloblastomas, were studied through immunohistochemistry using eleven monoclonal anti-CK antibodies. All central MECs expressed CKs 5, 7, 8, 14, and 18 and all GOCs expressed CKs 5, 7, 8, 13, 14, and 19. Comparing CK expression from GOC and central MEC we found differences in CKs 18 (30% vs 100%) and 19 (100% vs 50%). Central MEC and GOC are probably distinct entities with CK profiles similar to lesions of glandular and odontogenic origins, respectively, and expression of CKs 18 and 19 could be useful in their differential diagnosis.
ISSN:1368-8375
1879-0593
DOI:10.1016/j.oraloncology.2003.11.007