Memory impairment and auditory evoked potential gating deficit in schizophrenia

• Published in: Psychiatry research 2004-02, Vol.130 (2), p.161-169
• Main Authors: Hsieh, Ming H., Liu, Kristina, Liu, Shi-Kai, Chiu, Ming-Jang, Hwu, Hai-Gwo, Chen, Andrew C.N.
• Format: Article
• Language: English
• Subjects: Adult; Adult and adolescent clinical studies; Arousal - physiology; Artificial grammar; Attention - physiology; Auditory evoked potentials; Biological and medical sciences; Cerebral Cortex - physiopathology; Color Perception - physiology; Discrimination Learning - physiology; Dominance, Cerebral - physiology; Electroencephalography; Evoked Potentials, Auditory - physiology; Female; Fundamental and applied biological sciences. Psychology; Human; Humans; Image Processing, Computer-Assisted; Imaging, Three-Dimensional; Implicit learning; Learning. Memory; Male; Medical sciences; Memory; Memory Disorders - diagnosis; Memory Disorders - physiopathology; Memory, Short-Term - physiology; Middle Aged; Neuropsychological Tests; P50; Paired-Associate Learning - physiology; Pattern Recognition, Visual - physiology; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Psychopathology. Psychiatry; Psychoses; Reaction Time - physiology; Reading; Schizophrenia; Schizophrenia - diagnosis; Schizophrenia - physiopathology; Schizophrenic Psychology; Semantics; Sensory gating; Serial Learning - physiology; Signal Processing, Computer-Assisted
• ISSN: 0925-4927; 0165-1781; 1872-7506
• DOI: 10.1016/j.pscychresns.2002.12.001

Impaired sensory gating and memory function were reported in a study of 10 schizophrenic patients and 10 age- and sex-matched normal subjects. The P50 component of the auditory evoked potential was used as an index of gating. Explicit memory was tested with the Wechsler Memory Scale and implicit memory by artificial grammar learning. The schizophrenic patients showed deficits in both verbal paired associate and visual reproduction tasks. They demonstrated impaired implicit learning in color patterns but not letter strings. They also showed impaired P50 sensory gating. Three-dimensional brain mapping revealed a differential distribution of brain potentials in the processing of S1 and S2 at either P50 or N100 in both groups. However, the group difference was not statistically confirmed. In the controls, both implicit letter-string learning and explicit verbal paired associates were positively correlated with N100 gating, suggesting an association of the early attentive component with lexicons. In the schizophrenic patients, color-pattern implicit learning was positively correlated with P50 gating. The modality-specific impairment of implicit learning in schizophrenia may reflect a failure of adaptive filtering on the flooding input from color patterns.