In vivo and in vitro effects of different anaesthetics on platelet function

Summary Different effects of thiopental, propofol and sevoflurane on platelets have been reported. Patients undergoing thyroid surgery were anaesthetized with thiopental–fentanyl–sevoflurane (n = 11) or propofol–fentanyl–sevoflurane (n = 9). Platelet aggregation and thromboxane A2 generation were st...

Full description

Saved in:
Bibliographic Details
Published in:British journal of haematology 2004-04, Vol.125 (1), p.79-82
Main Authors: Dordoni, Pier Lorenza, Frassanito, Luciano, Bruno, Maria F., Proietti, Rodolfo, Cristofaro, Raimondo De, Ciabattoni, Giovanni, Ardito, Guglielmo, Crocchiolo, Roberto, Landolfi, Raffaele, Rocca, Bianca
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
aggregation
anaesthesia
Anesthetics, Combined - pharmacology
Anesthetics, Inhalation - pharmacology
Anesthetics, Intravenous - pharmacology
Biological and medical sciences
Blood Platelets - drug effects
Cells, Cultured
Dose-Response Relationship, Drug
Female
Hematologic and hematopoietic diseases
Hematology
Humans
Male
Medical sciences
Middle Aged
Platelet Aggregation - drug effects
platelets
Postoperative Period
propofol
Propofol - pharmacology
thiopental
Thiopental - pharmacology
Thromboxane A2 - biosynthesis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary Different effects of thiopental, propofol and sevoflurane on platelets have been reported. Patients undergoing thyroid surgery were anaesthetized with thiopental–fentanyl–sevoflurane (n = 11) or propofol–fentanyl–sevoflurane (n = 9). Platelet aggregation and thromboxane A2 generation were studied at baseline, and at the end of anaesthesia induction and surgery. Dose–response experiments were also performed in vitro with single agents. Thiopental–fentanyl–sevoflurane significantly reduced collagen‐induced aggregation by the end of induction, while ADP‐induced aggregation and thromboxane generation were unaffected. Propofol–fentanyl–sevoflurane had no effect on platelets. Thiopental dose‐dependently inhibited platelets in vitro, while fentanyl or propofol did not. In conclusion, thiopental reduces platelet function both ex vivo and in vitro and propofol might be considered haemostatically safer.
ISSN:0007-1048
1365-2141
DOI:10.1111/j.1365-2141.2004.04859.x