Blunted coronary flow reserve in systemic sclerosis

Objectives. We investigated whether the non-invasive determination of coronary flow reserve (CFR), as evaluated by transthoracic Doppler echocardiography, might be a potential method to detect early dysfunction of cardiovascular system in patients affected by systemic sclerosis (SSc) without clinica...

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Published in:Rheumatology (Oxford, England) England), 2004-04, Vol.43 (4), p.505-509
Main Authors: Sulli, A., Ghio, M., Bezante, G. P., Deferrari, L., Craviotto, C., Sebastiani, V., Setti, M., Barsotti, A., Cutolo, M., Indiveri, F.
Format: Article
Language:English
Subjects:
Adult
Aged
Autoantibodies - blood
Biological and medical sciences
Blood Flow Velocity
Coronary Circulation
Coronary flow reserve
Coronary Vessels - diagnostic imaging
Coronary Vessels - physiopathology
Diseases of the osteoarticular system
Doppler echocardiography
Echocardiography
Female
Heart disease
Humans
Male
Medical sciences
Middle Aged
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Scleroderma, Systemic - diagnostic imaging
Scleroderma, Systemic - physiopathology
Systemic sclerosis
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Summary:Objectives. We investigated whether the non-invasive determination of coronary flow reserve (CFR), as evaluated by transthoracic Doppler echocardiography, might be a potential method to detect early dysfunction of cardiovascular system in patients affected by systemic sclerosis (SSc) without clinical signs or symptoms of cardiac impairment. The possible correlations between the CFR values and the duration of the disease, specific autoantibodies and cutaneous involvement subsets were investigated. Methods. Forty-four consecutive patients affected by SSc were analysed. The CFR was detected in the distal left anterior descending coronary artery by contrast-enhanced transthoracic second harmonic Doppler in all SSc patients and in 16 healthy controls. CFR was assessed at rest and during hyperaemia induced by administration of adenosine at 0.14 mg/kg/min over 5 min. The CFR was calculated as the ratio between hyperaemic (peak adenosine infusion) and resting peak diastolic velocity (PdvCFR) and resting velocity time integral (VtiCFR). Past medical history was carefully investigated. Results. Both PdvCFR and VtiCFR were significantly reduced in SSc patients when compared with controls (P
ISSN:1462-0324
1462-0332
DOI:10.1093/rheumatology/keh087