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Efficacy and safety of selamectin against fleas on dogs and cats presented as veterinary patients in Europe
Two controlled and masked multi-centre studies were conducted to examine the efficacy of a novel topical avermectin, selamectin, against natural flea infestations on 418 dogs and 345 cats. Veterinary patients with viable flea infestations were enrolled in the studies, which were conducted in United...
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| Published in: | Veterinary parasitology 2000-08, Vol.91 (3), p.223-232 |
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| container_title | Veterinary parasitology |
| container_volume | 91 |
| creator | Benchaoui, H.A Clemence, R.G Clements, P.J.M Jones, R.L Watson, P Shanks, D.J Smith, D.G Sture, G.H Jernigan, A.D Rowan, T.G |
| description | Two controlled and masked multi-centre studies were conducted to examine the efficacy of a novel topical avermectin, selamectin, against natural flea infestations on 418 dogs and 345 cats. Veterinary patients with viable flea infestations were enrolled in the studies, which were conducted in United Kingdom, France, Germany, and Italy. Animals were allocated randomly in a 2:1 ratio to one of two treatments: either selamectin alone at a minimum dosage of 6
mg
kg
−1 or fenthion at recommended dose rates. Concurrent use of an environmental spray (containing methoprene and either pyrethrins or permethrin) was permitted only for fenthion-treated animals. In-contact cats and dogs (animals living in the same home) received the same treatment as the first animal enrolled from the household, if recommended by the veterinarian. Study day 0 was defined as the day of first treatment. Animals were treated on days 0, 30, and 60, and flea comb counts and clinical evaluations were conducted on days 0, 14, 30, 60, and 90. Analysis of variance of ln(flea count+1) showed that values were significantly lower for selamectin alone compared with fenthion (with or without the concurrent use of an environmental spray) in dogs on days 30, 60, and 90 (
P |
| doi_str_mv | 10.1016/S0304-4017(00)00294-6 |
| format | article |
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mg
kg
−1 or fenthion at recommended dose rates. Concurrent use of an environmental spray (containing methoprene and either pyrethrins or permethrin) was permitted only for fenthion-treated animals. In-contact cats and dogs (animals living in the same home) received the same treatment as the first animal enrolled from the household, if recommended by the veterinarian. Study day 0 was defined as the day of first treatment. Animals were treated on days 0, 30, and 60, and flea comb counts and clinical evaluations were conducted on days 0, 14, 30, 60, and 90. Analysis of variance of ln(flea count+1) showed that values were significantly lower for selamectin alone compared with fenthion (with or without the concurrent use of an environmental spray) in dogs on days 30, 60, and 90 (
P<0.05) and in cats on days 14, 30, 60, and 90 (
P<0.01). For selamectin, the reductions in geometric mean flea counts on days 14, 30, 60, and 90, compared with day 0, were 92.5, 90.7, 98.1, and 99.1%, respectively, for dogs and 92.8, 92.7, 97.7, and 98.4%, respectively, for cats. Selamectin was shown to be safe and highly effective in the control of naturally acquired flea infestations on dogs and cats presented as veterinary patients in Europe.</description><identifier>ISSN: 0304-4017</identifier><identifier>EISSN: 1873-2550</identifier><identifier>DOI: 10.1016/S0304-4017(00)00294-6</identifier><identifier>PMID: 10940524</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Antiparasitic Agents - administration & dosage ; Antiparasitic Agents - therapeutic use ; avermectin ; Avermectins ; Cat Diseases - drug therapy ; Cats ; Ctenocephalides ; Dog Diseases - drug therapy ; Dogs ; Drug Administration Schedule ; Ectoparasitic Infestations - drug therapy ; Ectoparasitic Infestations - veterinary ; Europe ; Female ; Fleas ; Housing, Animal ; Ivermectin - analogs & derivatives ; Ivermectin - therapeutic use ; Male ; Revolution ; Selamectin ; Siphonaptera - drug effects ; Stronghold</subject><ispartof>Veterinary parasitology, 2000-08, Vol.91 (3), p.223-232</ispartof><rights>2000 Elsevier Science B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-cd6db2610cd1fff532594557c2cd018780203681b098e698b97884a3d5211a533</citedby><cites>FETCH-LOGICAL-c392t-cd6db2610cd1fff532594557c2cd018780203681b098e698b97884a3d5211a533</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10940524$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Benchaoui, H.A</creatorcontrib><creatorcontrib>Clemence, R.G</creatorcontrib><creatorcontrib>Clements, P.J.M</creatorcontrib><creatorcontrib>Jones, R.L</creatorcontrib><creatorcontrib>Watson, P</creatorcontrib><creatorcontrib>Shanks, D.J</creatorcontrib><creatorcontrib>Smith, D.G</creatorcontrib><creatorcontrib>Sture, G.H</creatorcontrib><creatorcontrib>Jernigan, A.D</creatorcontrib><creatorcontrib>Rowan, T.G</creatorcontrib><title>Efficacy and safety of selamectin against fleas on dogs and cats presented as veterinary patients in Europe</title><title>Veterinary parasitology</title><addtitle>Vet Parasitol</addtitle><description>Two controlled and masked multi-centre studies were conducted to examine the efficacy of a novel topical avermectin, selamectin, against natural flea infestations on 418 dogs and 345 cats. Veterinary patients with viable flea infestations were enrolled in the studies, which were conducted in United Kingdom, France, Germany, and Italy. Animals were allocated randomly in a 2:1 ratio to one of two treatments: either selamectin alone at a minimum dosage of 6
mg
kg
−1 or fenthion at recommended dose rates. Concurrent use of an environmental spray (containing methoprene and either pyrethrins or permethrin) was permitted only for fenthion-treated animals. In-contact cats and dogs (animals living in the same home) received the same treatment as the first animal enrolled from the household, if recommended by the veterinarian. Study day 0 was defined as the day of first treatment. Animals were treated on days 0, 30, and 60, and flea comb counts and clinical evaluations were conducted on days 0, 14, 30, 60, and 90. Analysis of variance of ln(flea count+1) showed that values were significantly lower for selamectin alone compared with fenthion (with or without the concurrent use of an environmental spray) in dogs on days 30, 60, and 90 (
P<0.05) and in cats on days 14, 30, 60, and 90 (
P<0.01). For selamectin, the reductions in geometric mean flea counts on days 14, 30, 60, and 90, compared with day 0, were 92.5, 90.7, 98.1, and 99.1%, respectively, for dogs and 92.8, 92.7, 97.7, and 98.4%, respectively, for cats. Selamectin was shown to be safe and highly effective in the control of naturally acquired flea infestations on dogs and cats presented as veterinary patients in Europe.</description><subject>Animals</subject><subject>Antiparasitic Agents - administration & dosage</subject><subject>Antiparasitic Agents - therapeutic use</subject><subject>avermectin</subject><subject>Avermectins</subject><subject>Cat Diseases - drug therapy</subject><subject>Cats</subject><subject>Ctenocephalides</subject><subject>Dog Diseases - drug therapy</subject><subject>Dogs</subject><subject>Drug Administration Schedule</subject><subject>Ectoparasitic Infestations - drug therapy</subject><subject>Ectoparasitic Infestations - veterinary</subject><subject>Europe</subject><subject>Female</subject><subject>Fleas</subject><subject>Housing, Animal</subject><subject>Ivermectin - analogs & derivatives</subject><subject>Ivermectin - therapeutic use</subject><subject>Male</subject><subject>Revolution</subject><subject>Selamectin</subject><subject>Siphonaptera - drug effects</subject><subject>Stronghold</subject><issn>0304-4017</issn><issn>1873-2550</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNqFkUFvFDEMhSMEokvhJ1DlhOAwYGeSzMypQtVCK1XqoXCOsolTBWZnpkm20v570t2q4taTJfuzn_weYx8RviKg_nYLLchGAnafAb4AiEE2-hVbYd-1jVAKXrPVM3LC3uX8BwAk6O4tO0EYJCghV-zvOoTorNtzO3mebaCy53PgmUa7JVfixO2djVMuPIxkM58n7ue7fMCdLZkviTJNhTyv0wcqlOJk054vtsTaz7yeWO_SvNB79ibYMdOHp3rKfv9Y_7q4bK5vfl5dfL9uXDuI0jiv_UZoBOcxhKBaoQapVOeE81Df60FAq3vcwNCTHvrN0PW9tK1XAtGqtj1ln453lzTf7ygXs43Z0TjaieZdNh12CiWqF0GsWhoVVFAdQZfmnBMFs6S4rV8aBPMYhznEYR69NgDmEIfRde_sSWC32ZL_b-vofwXOjwBVPx4iJZNddc2Rj6m6b_wcX5D4B0DOmR0</recordid><startdate>20000823</startdate><enddate>20000823</enddate><creator>Benchaoui, H.A</creator><creator>Clemence, R.G</creator><creator>Clements, P.J.M</creator><creator>Jones, R.L</creator><creator>Watson, P</creator><creator>Shanks, D.J</creator><creator>Smith, D.G</creator><creator>Sture, G.H</creator><creator>Jernigan, A.D</creator><creator>Rowan, T.G</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7X8</scope></search><sort><creationdate>20000823</creationdate><title>Efficacy and safety of selamectin against fleas on dogs and cats presented as veterinary patients in Europe</title><author>Benchaoui, H.A ; 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Veterinary patients with viable flea infestations were enrolled in the studies, which were conducted in United Kingdom, France, Germany, and Italy. Animals were allocated randomly in a 2:1 ratio to one of two treatments: either selamectin alone at a minimum dosage of 6
mg
kg
−1 or fenthion at recommended dose rates. Concurrent use of an environmental spray (containing methoprene and either pyrethrins or permethrin) was permitted only for fenthion-treated animals. In-contact cats and dogs (animals living in the same home) received the same treatment as the first animal enrolled from the household, if recommended by the veterinarian. Study day 0 was defined as the day of first treatment. Animals were treated on days 0, 30, and 60, and flea comb counts and clinical evaluations were conducted on days 0, 14, 30, 60, and 90. Analysis of variance of ln(flea count+1) showed that values were significantly lower for selamectin alone compared with fenthion (with or without the concurrent use of an environmental spray) in dogs on days 30, 60, and 90 (
P<0.05) and in cats on days 14, 30, 60, and 90 (
P<0.01). For selamectin, the reductions in geometric mean flea counts on days 14, 30, 60, and 90, compared with day 0, were 92.5, 90.7, 98.1, and 99.1%, respectively, for dogs and 92.8, 92.7, 97.7, and 98.4%, respectively, for cats. Selamectin was shown to be safe and highly effective in the control of naturally acquired flea infestations on dogs and cats presented as veterinary patients in Europe.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>10940524</pmid><doi>10.1016/S0304-4017(00)00294-6</doi><tpages>10</tpages></addata></record> |
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| ispartof | Veterinary parasitology, 2000-08, Vol.91 (3), p.223-232 |
| issn | 0304-4017 1873-2550 |
| language | eng |
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| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Animals Antiparasitic Agents - administration & dosage Antiparasitic Agents - therapeutic use avermectin Avermectins Cat Diseases - drug therapy Cats Ctenocephalides Dog Diseases - drug therapy Dogs Drug Administration Schedule Ectoparasitic Infestations - drug therapy Ectoparasitic Infestations - veterinary Europe Female Fleas Housing, Animal Ivermectin - analogs & derivatives Ivermectin - therapeutic use Male Revolution Selamectin Siphonaptera - drug effects Stronghold |
| title | Efficacy and safety of selamectin against fleas on dogs and cats presented as veterinary patients in Europe |
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