Effect of mitragynine, derived from Thai folk medicine, on gastric acid secretion through opioid receptor in anesthetized rats

Mitragynine, an indole alkaloid from Thai folk medicine Mitragyna speciosa, exerts agonistic effects on opioid receptors. Gastric acid secretion is proposed to be regulated by opioid receptors in the central nervous system (CNS). Previously, we reported the dual roles (inhibition via μ-opioid recept...

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Bibliographic Details
Published in:European journal of pharmacology 2002-05, Vol.443 (1), p.185-188
Main Authors: Tsuchiya, Shizuko, Miyashita, Sanae, Yamamoto, Makiko, Horie, Syunji, Sakai, Shin-Ichiro, Aimi, Norio, Takayama, Hiromitsu, Watanabe, Kazuo
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Brain - metabolism
Central nervous system
Deoxyglucose - pharmacology
Digestive system
Gastric Acid - metabolism
Gastric acid secretion
Gastric Acidity Determination
General pharmacology
Injections, Intraventricular
Male
Medical sciences
Medicine, Traditional
Mitragynine
Morphine - pharmacology
Opioid receptor
Perfusion
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Rats
Rats, Wistar
Receptors, Opioid - agonists
Receptors, Opioid - metabolism
Secologanin Tryptamine Alkaloids - pharmacology
Thailand
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Summary:Mitragynine, an indole alkaloid from Thai folk medicine Mitragyna speciosa, exerts agonistic effects on opioid receptors. Gastric acid secretion is proposed to be regulated by opioid receptors in the central nervous system (CNS). Previously, we reported the dual roles (inhibition via μ-opioid receptors and stimulation via κ-opioid receptors) of the opioid system in the central control of gastric acid secretion. We investigated whether mitragynine affects gastric acid secretion via opioid receptors in the CNS. Injection of mitragynine (30 μg) alone into the lateral cerebroventricle did not have a significant effect on basal gastric acid secretion in the perfused stomach of anesthetized rats. Injection of mitragynine (3–30 μg) into the fourth cerebroventricle, like morphine, inhibited 2-deoxy- d-glucose-stimulated gastric acid secretion. The inhibitory effect of mitragynine (30 μg) was reversed by naloxone (100 μg). These results suggest that mitragynine has a morphine-like action on gastric acid secretion in the CNS.
ISSN:0014-2999
1879-0712
DOI:10.1016/S0014-2999(02)01588-1