Development of hyperthyroidism in a patient with idiopathic nephrotic syndrome

We present a 13-year-old boy who developed hyperthyroidism during the clinical course of idiopathic nephrotic syndrome treated with glucocorticoid. He had a second relapse of minimal change nephrotic syndrome, and complete remission of nephrotic syndrome was achieved immediately with oral glucocorti...

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Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 2002-05, Vol.17 (5), p.367-369
Main Authors: KUBOTA, Takuo, HIRAI, Haruhiko, SHIMIZU, Nobuhiko, SAWADA, Atsushi, KONDOU, Hiroki, NAKAJIMA, Shigeo, HARADA, Tokuzo, SHIMA, Masaaki
Format: Article
Language:English
Subjects:
Administration, Oral
Adolescent
Biological and medical sciences
Dose-Response Relationship, Drug
Drug Administration Schedule
Glomerulonephritis
Glucocorticoids - administration & dosage
Glucocorticoids - therapeutic use
Humans
Hyperthyroidism - complications
Male
Medical sciences
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
Nephrosis, Lipoid - complications
Nephrosis, Lipoid - drug therapy
Prednisolone - administration & dosage
Prednisolone - therapeutic use
Recurrence
Remission Induction
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Summary:We present a 13-year-old boy who developed hyperthyroidism during the clinical course of idiopathic nephrotic syndrome treated with glucocorticoid. He had a second relapse of minimal change nephrotic syndrome, and complete remission of nephrotic syndrome was achieved immediately with oral glucocorticoid. However, when the steroid dosage was reduced, signs of hyperthyroidism such as systolic hypertension and tachycardia were observed. Laboratory findings revealed thyroid-stimulating hormone (TSH) below 0.05 microU/ml, free tri-iodothyronine of 16.1 pg/ml, free thyroxine of 5.6 ng/dl, and anti-TSH receptor antibody of 90%. Thus, a diagnosis of hyperthyroidism was made and treatment with thiamazol was started. Massive proteinuria may decrease the activity of hyperthyroidism due to urinary loss of thyroid hormones. A decrease in glucocorticoid dosage may also be involved in the development of hyperthyroidism due to a reduced immunosuppressive effect.
ISSN:0931-041X
1432-198X
DOI:10.1007/s00467-002-0820-7