The transcriptome: malariologists ride the wave

The Plasmodium falciparum genome‐sequencing project has provided malariologists with vast amounts of new information pertinent to a multitude of cellular processes that previously were only guessed about. In exploring this morass of predicted genes and proteins, there is now a danger of simply re‐in...

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Bibliographic Details
Published in:BioEssays 2004-04, Vol.26 (4), p.339-342
Main Author: Wilson, R.J.M.(Iain)
Format: Article
Language:English
Subjects:
Animals
Genes, Protozoan
Genetic Variation
Genome, Protozoan
Models, Biological
Plasmodium falciparum
Plasmodium falciparum - genetics
Plasmodium falciparum - physiology
Proteome
Protozoan Proteins
RNA, Messenger - metabolism
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Summary:The Plasmodium falciparum genome‐sequencing project has provided malariologists with vast amounts of new information pertinent to a multitude of cellular processes that previously were only guessed about. In exploring this morass of predicted genes and proteins, there is now a danger of simply re‐inventing the cell. Fortunately, new global transcriptional analyses reassure malariologists that they are not dealing with just “any old cell.” The informative papers on the plasmodial transcriptome by Le Roch et al. (2003)1 and Bozdech et al. (2003)2 discussed below forge a bridge between the genomics and proteomics of P. falciparum. They are likely to act as a fulcrum upon which much future research will turn: for example, the study of regulation and feed‐back loops. BioEssays 26:339–342, 2004. © 2004 Wiley Periodicals, Inc.
ISSN:0265-9247
1521-1878
DOI:10.1002/bies.20025