The use of methohexital during chest tube removal in neonates

Summary Background : The aim of the study was the evaluation of the effect of methohexital during chest tube removal (CTR) in neonates. Methods : Evaluation was based on the degree of sedation (grades 1–4) and relaxation (grades 1–4) and trends in vital signs heart rate, mean arterial blood pressure...

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Bibliographic Details
Published in:Pediatric anesthesia 2004-04, Vol.14 (4), p.308-312
Main Authors: Allegaert, K., Naulaers, G., Debeer, A., Breysem, L., Ferens, I., Vanhole, C., Devlieger, H., Tibboel, D.
Format: Article
Language:English
Subjects:
Analgesics - therapeutic use
Anesthesia
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Anesthetics, Intravenous - administration & dosage
Biological and medical sciences
Birth Weight
Blood Pressure - drug effects
chest tube
Chest Tubes
Device Removal
Heart Rate - drug effects
Humans
Infant, Newborn
Medical sciences
methohexital
Methohexital - administration & dosage
Muscle Contraction - drug effects
neonates
Oxygen - blood
Pain Measurement
procedural pain relief
Prospective Studies
Respiration, Artificial
Statistics, Nonparametric
Time Factors
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Summary:Summary Background : The aim of the study was the evaluation of the effect of methohexital during chest tube removal (CTR) in neonates. Methods : Evaluation was based on the degree of sedation (grades 1–4) and relaxation (grades 1–4) and trends in vital signs heart rate, mean arterial blood pressure (MAP), oxygen saturation at time points (−10, −5, −3, −1, 0, 1, 3, 5, and 10 min) before and after administration of methohexital. A multidimensional pain scale [Leuven Neonatal Pain Scale (LNPS)] was used to evaluate pain expression. Effective sedation and relaxation (grade >2) would enable the physician to perform CTR without difficulties. Paired Wilcoxon was used to compare vital signs and pain expression before and after the procedure. Results : Twenty‐two procedures in 22 infants were recorded. Eleven infants were ventilated and 21 infants were having intravenous analgesics during CTR. Birth weight was 2645 g (range 1235–4500 g). Postnatal age was 6 days (range 1–80 days). Methohexital had no effect on ventilatory weaning, MAP or oxygen saturation. Heart rate increased from 144 (49) to 162 (43) (P = 0.012) b·min−1. Sedation and relaxation were effective (>grade 2) and lasted for
ISSN:1155-5645
1460-9592
DOI:10.1046/j.1460-9592.2003.01187.x