Loading…
OTK18 expression in brain mononuclear phagocytes parallels the severity of HIV-1 encephalitis
OTK18 was isolated by mRNA differential display of human monocyte-derived macrophages (MDM) infected with human immunodeficiency virus type one (HIV-1). Northern blot and real-time reverse transcription polymerase chain reaction showed low levels of OTK18 expression in human tissue, which markedly i...
Saved in:
| Published in: | Journal of neuroimmunology 2004-05, Vol.150 (1), p.186-198 |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c395t-ce833e17f65ae54dcbf427a3a32e441ef52ea1af5e8abff22cb807c063a074993 |
|---|---|
| cites | |
| container_end_page | 198 |
| container_issue | 1 |
| container_start_page | 186 |
| container_title | Journal of neuroimmunology |
| container_volume | 150 |
| creator | Carlson, Kimberly A. Limoges, Jenae Pohlman, Garrett D. Poluektova, Larisa Y. Langford, Dianne Masliah, Eliezer Ikezu, Tsuneya Gendelman, Howard E. |
| description | OTK18 was isolated by mRNA differential display of human monocyte-derived macrophages (MDM) infected with human immunodeficiency virus type one (HIV-1). Northern blot and real-time reverse transcription polymerase chain reaction showed low levels of OTK18 expression in human tissue, which markedly increased during advanced HIV-1 encephalitis (HIVE). Immunocytochemistry, using rabbit polyclonal antisera, showed OTK18 localized to brain mononuclear phagocytes (MP) in moderate to severe HIV-1 encephalitis. OTK18 expression was selective and not found in HIV-1-infected brain tissue with limited neuropathological abnormalities, nor in cytomegalovirus encephalitis, multiple sclerosis, Alzheimer's disease, or uninfected control brains. Thus, OTK18 expression in brain mononuclear phagocytes is a signature for advanced HIV-1 encephalitis. |
| doi_str_mv | 10.1016/j.jneuroim.2004.01.021 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71824394</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0165572804000426</els_id><sourcerecordid>17795077</sourcerecordid><originalsourceid>FETCH-LOGICAL-c395t-ce833e17f65ae54dcbf427a3a32e441ef52ea1af5e8abff22cb807c063a074993</originalsourceid><addsrcrecordid>eNqFkU1v1DAQhi0EapfSv1D5xC3B44_YuYEqaCsq9VK4IcvxjqlXSRzspGL_fbPaRRx7mbk874z0PoRcAauBQfNpV-9GXHKKQ80ZkzWDmnF4QzZgNK-M5PCWbFZQVUpzc07el7JjDJSQ7Rk5B8UM8EZuyK-Hx-9gKP6dMpYS00jjSLvs1jmkMY2L79FlOj2538nvZyx0ctn1PfaFzk9ICz5jjvOepkBv735WQHH0uOJ9nGP5QN4F1xe8PO0L8uPb18fr2-r-4ebu-st95UWr5sqjEQJBh0Y5VHLruyC5dsIJjlICBsXRgQsKjetC4Nx3hmnPGuGYlm0rLsjH490ppz8LltkOsXjsezdiWorVYLgUrXwVBK1bxbReweYI-pxKyRjslOPg8t4CswcDdmf_GbAHA5aBXQ2swavTh6UbcPs_dqp8BT4fgbVCfI6YbfHxUNo2ZvSz3ab42o8Xi-qb6A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17795077</pqid></control><display><type>article</type><title>OTK18 expression in brain mononuclear phagocytes parallels the severity of HIV-1 encephalitis</title><source>ScienceDirect Freedom Collection</source><creator>Carlson, Kimberly A. ; Limoges, Jenae ; Pohlman, Garrett D. ; Poluektova, Larisa Y. ; Langford, Dianne ; Masliah, Eliezer ; Ikezu, Tsuneya ; Gendelman, Howard E.</creator><creatorcontrib>Carlson, Kimberly A. ; Limoges, Jenae ; Pohlman, Garrett D. ; Poluektova, Larisa Y. ; Langford, Dianne ; Masliah, Eliezer ; Ikezu, Tsuneya ; Gendelman, Howard E.</creatorcontrib><description>OTK18 was isolated by mRNA differential display of human monocyte-derived macrophages (MDM) infected with human immunodeficiency virus type one (HIV-1). Northern blot and real-time reverse transcription polymerase chain reaction showed low levels of OTK18 expression in human tissue, which markedly increased during advanced HIV-1 encephalitis (HIVE). Immunocytochemistry, using rabbit polyclonal antisera, showed OTK18 localized to brain mononuclear phagocytes (MP) in moderate to severe HIV-1 encephalitis. OTK18 expression was selective and not found in HIV-1-infected brain tissue with limited neuropathological abnormalities, nor in cytomegalovirus encephalitis, multiple sclerosis, Alzheimer's disease, or uninfected control brains. Thus, OTK18 expression in brain mononuclear phagocytes is a signature for advanced HIV-1 encephalitis.</description><identifier>ISSN: 0165-5728</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/j.jneuroim.2004.01.021</identifier><identifier>PMID: 15081264</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>AIDS Dementia Complex - immunology ; AIDS Dementia Complex - metabolism ; AIDS Dementia Complex - pathology ; Brain - cytology ; Brain - immunology ; Brain - metabolism ; Cells, Cultured ; Cytomegalovirus ; Disease markers ; Disease Progression ; DNA-Binding Proteins - biosynthesis ; DNA-Binding Proteins - genetics ; Encephalitis, Viral - immunology ; Encephalitis, Viral - metabolism ; Encephalitis, Viral - pathology ; Gene Expression Regulation - immunology ; HIV-1 - immunology ; HIV-1 encephalitis ; Human immunodeficiency virus 1 ; Humans ; Macrophages ; Macrophages - immunology ; Macrophages - metabolism ; Macrophages - virology ; Microglia ; Organ Specificity - genetics ; Organ Specificity - immunology ; Severity of Illness Index ; Transcription Factors - biosynthesis ; Transcription Factors - genetics ; Transcriptional factor ; Virus Replication - genetics ; Virus Replication - immunology</subject><ispartof>Journal of neuroimmunology, 2004-05, Vol.150 (1), p.186-198</ispartof><rights>2004 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c395t-ce833e17f65ae54dcbf427a3a32e441ef52ea1af5e8abff22cb807c063a074993</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15081264$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carlson, Kimberly A.</creatorcontrib><creatorcontrib>Limoges, Jenae</creatorcontrib><creatorcontrib>Pohlman, Garrett D.</creatorcontrib><creatorcontrib>Poluektova, Larisa Y.</creatorcontrib><creatorcontrib>Langford, Dianne</creatorcontrib><creatorcontrib>Masliah, Eliezer</creatorcontrib><creatorcontrib>Ikezu, Tsuneya</creatorcontrib><creatorcontrib>Gendelman, Howard E.</creatorcontrib><title>OTK18 expression in brain mononuclear phagocytes parallels the severity of HIV-1 encephalitis</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>OTK18 was isolated by mRNA differential display of human monocyte-derived macrophages (MDM) infected with human immunodeficiency virus type one (HIV-1). Northern blot and real-time reverse transcription polymerase chain reaction showed low levels of OTK18 expression in human tissue, which markedly increased during advanced HIV-1 encephalitis (HIVE). Immunocytochemistry, using rabbit polyclonal antisera, showed OTK18 localized to brain mononuclear phagocytes (MP) in moderate to severe HIV-1 encephalitis. OTK18 expression was selective and not found in HIV-1-infected brain tissue with limited neuropathological abnormalities, nor in cytomegalovirus encephalitis, multiple sclerosis, Alzheimer's disease, or uninfected control brains. Thus, OTK18 expression in brain mononuclear phagocytes is a signature for advanced HIV-1 encephalitis.</description><subject>AIDS Dementia Complex - immunology</subject><subject>AIDS Dementia Complex - metabolism</subject><subject>AIDS Dementia Complex - pathology</subject><subject>Brain - cytology</subject><subject>Brain - immunology</subject><subject>Brain - metabolism</subject><subject>Cells, Cultured</subject><subject>Cytomegalovirus</subject><subject>Disease markers</subject><subject>Disease Progression</subject><subject>DNA-Binding Proteins - biosynthesis</subject><subject>DNA-Binding Proteins - genetics</subject><subject>Encephalitis, Viral - immunology</subject><subject>Encephalitis, Viral - metabolism</subject><subject>Encephalitis, Viral - pathology</subject><subject>Gene Expression Regulation - immunology</subject><subject>HIV-1 - immunology</subject><subject>HIV-1 encephalitis</subject><subject>Human immunodeficiency virus 1</subject><subject>Humans</subject><subject>Macrophages</subject><subject>Macrophages - immunology</subject><subject>Macrophages - metabolism</subject><subject>Macrophages - virology</subject><subject>Microglia</subject><subject>Organ Specificity - genetics</subject><subject>Organ Specificity - immunology</subject><subject>Severity of Illness Index</subject><subject>Transcription Factors - biosynthesis</subject><subject>Transcription Factors - genetics</subject><subject>Transcriptional factor</subject><subject>Virus Replication - genetics</subject><subject>Virus Replication - immunology</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNqFkU1v1DAQhi0EapfSv1D5xC3B44_YuYEqaCsq9VK4IcvxjqlXSRzspGL_fbPaRRx7mbk874z0PoRcAauBQfNpV-9GXHKKQ80ZkzWDmnF4QzZgNK-M5PCWbFZQVUpzc07el7JjDJSQ7Rk5B8UM8EZuyK-Hx-9gKP6dMpYS00jjSLvs1jmkMY2L79FlOj2538nvZyx0ctn1PfaFzk9ICz5jjvOepkBv735WQHH0uOJ9nGP5QN4F1xe8PO0L8uPb18fr2-r-4ebu-st95UWr5sqjEQJBh0Y5VHLruyC5dsIJjlICBsXRgQsKjetC4Nx3hmnPGuGYlm0rLsjH490ppz8LltkOsXjsezdiWorVYLgUrXwVBK1bxbReweYI-pxKyRjslOPg8t4CswcDdmf_GbAHA5aBXQ2swavTh6UbcPs_dqp8BT4fgbVCfI6YbfHxUNo2ZvSz3ab42o8Xi-qb6A</recordid><startdate>20040501</startdate><enddate>20040501</enddate><creator>Carlson, Kimberly A.</creator><creator>Limoges, Jenae</creator><creator>Pohlman, Garrett D.</creator><creator>Poluektova, Larisa Y.</creator><creator>Langford, Dianne</creator><creator>Masliah, Eliezer</creator><creator>Ikezu, Tsuneya</creator><creator>Gendelman, Howard E.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20040501</creationdate><title>OTK18 expression in brain mononuclear phagocytes parallels the severity of HIV-1 encephalitis</title><author>Carlson, Kimberly A. ; Limoges, Jenae ; Pohlman, Garrett D. ; Poluektova, Larisa Y. ; Langford, Dianne ; Masliah, Eliezer ; Ikezu, Tsuneya ; Gendelman, Howard E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c395t-ce833e17f65ae54dcbf427a3a32e441ef52ea1af5e8abff22cb807c063a074993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>AIDS Dementia Complex - immunology</topic><topic>AIDS Dementia Complex - metabolism</topic><topic>AIDS Dementia Complex - pathology</topic><topic>Brain - cytology</topic><topic>Brain - immunology</topic><topic>Brain - metabolism</topic><topic>Cells, Cultured</topic><topic>Cytomegalovirus</topic><topic>Disease markers</topic><topic>Disease Progression</topic><topic>DNA-Binding Proteins - biosynthesis</topic><topic>DNA-Binding Proteins - genetics</topic><topic>Encephalitis, Viral - immunology</topic><topic>Encephalitis, Viral - metabolism</topic><topic>Encephalitis, Viral - pathology</topic><topic>Gene Expression Regulation - immunology</topic><topic>HIV-1 - immunology</topic><topic>HIV-1 encephalitis</topic><topic>Human immunodeficiency virus 1</topic><topic>Humans</topic><topic>Macrophages</topic><topic>Macrophages - immunology</topic><topic>Macrophages - metabolism</topic><topic>Macrophages - virology</topic><topic>Microglia</topic><topic>Organ Specificity - genetics</topic><topic>Organ Specificity - immunology</topic><topic>Severity of Illness Index</topic><topic>Transcription Factors - biosynthesis</topic><topic>Transcription Factors - genetics</topic><topic>Transcriptional factor</topic><topic>Virus Replication - genetics</topic><topic>Virus Replication - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carlson, Kimberly A.</creatorcontrib><creatorcontrib>Limoges, Jenae</creatorcontrib><creatorcontrib>Pohlman, Garrett D.</creatorcontrib><creatorcontrib>Poluektova, Larisa Y.</creatorcontrib><creatorcontrib>Langford, Dianne</creatorcontrib><creatorcontrib>Masliah, Eliezer</creatorcontrib><creatorcontrib>Ikezu, Tsuneya</creatorcontrib><creatorcontrib>Gendelman, Howard E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carlson, Kimberly A.</au><au>Limoges, Jenae</au><au>Pohlman, Garrett D.</au><au>Poluektova, Larisa Y.</au><au>Langford, Dianne</au><au>Masliah, Eliezer</au><au>Ikezu, Tsuneya</au><au>Gendelman, Howard E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>OTK18 expression in brain mononuclear phagocytes parallels the severity of HIV-1 encephalitis</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>2004-05-01</date><risdate>2004</risdate><volume>150</volume><issue>1</issue><spage>186</spage><epage>198</epage><pages>186-198</pages><issn>0165-5728</issn><eissn>1872-8421</eissn><abstract>OTK18 was isolated by mRNA differential display of human monocyte-derived macrophages (MDM) infected with human immunodeficiency virus type one (HIV-1). Northern blot and real-time reverse transcription polymerase chain reaction showed low levels of OTK18 expression in human tissue, which markedly increased during advanced HIV-1 encephalitis (HIVE). Immunocytochemistry, using rabbit polyclonal antisera, showed OTK18 localized to brain mononuclear phagocytes (MP) in moderate to severe HIV-1 encephalitis. OTK18 expression was selective and not found in HIV-1-infected brain tissue with limited neuropathological abnormalities, nor in cytomegalovirus encephalitis, multiple sclerosis, Alzheimer's disease, or uninfected control brains. Thus, OTK18 expression in brain mononuclear phagocytes is a signature for advanced HIV-1 encephalitis.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>15081264</pmid><doi>10.1016/j.jneuroim.2004.01.021</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0165-5728 |
| ispartof | Journal of neuroimmunology, 2004-05, Vol.150 (1), p.186-198 |
| issn | 0165-5728 1872-8421 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71824394 |
| source | ScienceDirect Freedom Collection |
| subjects | AIDS Dementia Complex - immunology AIDS Dementia Complex - metabolism AIDS Dementia Complex - pathology Brain - cytology Brain - immunology Brain - metabolism Cells, Cultured Cytomegalovirus Disease markers Disease Progression DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - genetics Encephalitis, Viral - immunology Encephalitis, Viral - metabolism Encephalitis, Viral - pathology Gene Expression Regulation - immunology HIV-1 - immunology HIV-1 encephalitis Human immunodeficiency virus 1 Humans Macrophages Macrophages - immunology Macrophages - metabolism Macrophages - virology Microglia Organ Specificity - genetics Organ Specificity - immunology Severity of Illness Index Transcription Factors - biosynthesis Transcription Factors - genetics Transcriptional factor Virus Replication - genetics Virus Replication - immunology |
| title | OTK18 expression in brain mononuclear phagocytes parallels the severity of HIV-1 encephalitis |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T07%3A12%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=OTK18%20expression%20in%20brain%20mononuclear%20phagocytes%20parallels%20the%20severity%20of%20HIV-1%20encephalitis&rft.jtitle=Journal%20of%20neuroimmunology&rft.au=Carlson,%20Kimberly%20A.&rft.date=2004-05-01&rft.volume=150&rft.issue=1&rft.spage=186&rft.epage=198&rft.pages=186-198&rft.issn=0165-5728&rft.eissn=1872-8421&rft_id=info:doi/10.1016/j.jneuroim.2004.01.021&rft_dat=%3Cproquest_cross%3E17795077%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c395t-ce833e17f65ae54dcbf427a3a32e441ef52ea1af5e8abff22cb807c063a074993%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=17795077&rft_id=info:pmid/15081264&rfr_iscdi=true |