Fluorescence detection of a new photosensitizer, PAD-S31, in tumour tissues and its use as a photodynamic treatment for skin tumours in dogs and a cat: a preliminary report

We describe here the detection by fluorescence of a new photosensitizer, PAD-S31, in tumours in dogs and cats and the effect of photodynamic therapy (PDT) by using PAD-S31 for skin tumours in two dogs and one cat. PAD-S31 is a hydrophilic photosensitizer that has two peaks at absorption wavelengths...

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Bibliographic Details
Published in:The veterinary journal (1997) 2004-05, Vol.167 (3), p.286-293
Main Authors: Tanabe, S, Yamaguchi, M, Iijima, M, Nakajima, S, Sakata, I, Miyaki, S, Takemura, T, Furuoka, H, Kobayashi, Y, Matsui, T, Uzuka, Y, Sarashina, T
Format: Article
Language:English
Subjects:
Animals
Cat Diseases - drug therapy
Cats
Cell Line, Tumor
Dog Diseases - drug therapy
Dogs
Female
Male
Mice
Mice, Inbred BALB C
Mice, Inbred C3H
Naturally occurring tumours
Photochemotherapy - methods
Photochemotherapy - veterinary
Photodynamic diagnosis
Photodynamic therapy
Photosensitizer
Photosensitizing Agents - therapeutic use
Porphyrins - therapeutic use
Skin Neoplasms - drug therapy
Skin Neoplasms - veterinary
Small animal practice
Spectrometry, Fluorescence
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Summary:We describe here the detection by fluorescence of a new photosensitizer, PAD-S31, in tumours in dogs and cats and the effect of photodynamic therapy (PDT) by using PAD-S31 for skin tumours in two dogs and one cat. PAD-S31 is a hydrophilic photosensitizer that has two peaks at absorption wavelengths 406 and 665 nm in distilled water. In a preliminary experiment in mice transplanted with SCCVII and colon 26, PAD-S31 was retained in tumour tissues rather than in other organs. The tumours resected from dogs and cats after intravenous administration of PAD-S31 at a dose of 15 mg/kg emitted strong red fluorescence under light illumination of 402 nm wavelength. Animals given PAD-S31 showed no cutaneous photosensitivity under room light illumination. Irradiation at laser light 670 nm wavelength (fluence rate 150 mW/cm 2 and total light dosage 150 J/cm 2) on cutaneous mast cell tumours in dogs ( n=2) and a cutaneous basal cell tumour in a cat induced complete remission. These results suggest PAD-S31 could be a promising photosensitizer for use in a small animal veterinary practice.
ISSN:1090-0233
1532-2971
DOI:10.1016/j.tvjl.2003.07.001