Age-related decline of serotonin transporters in living human brain of healthy males

There is growing interest in serotonin transporter (5-HTT) function in the human brain, since alteration in 5-HTT has been suggested in a variety of neurophychiatric disorders. Age-related decline in postsynaptic 5-HT receptors has been demonstrated in postmortem human studies and in vivo imaging st...

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Bibliographic Details
Published in:Life sciences (1973) 2002-07, Vol.71 (7), p.751-757
Main Authors: Yamamoto, Masahiro, Suhara, Tetsuya, Okubo, Yoshiro, Ichimiya, Tetsuya, Sudo, Yasuhiko, Inoue, Makoto, Takano, Akihiro, Yasuno, Fumihiko, Yoshikawa, Kyosan, Tanada, Shuji
Format: Article
Language:English
Subjects:
[ 11C](+)McN5652
Adult
Aged
Aging
Aging - physiology
Algorithms
Brain Chemistry - physiology
Carrier Proteins - metabolism
Cerebellum - growth & development
Cerebellum - metabolism
Humans
Image Processing, Computer-Assisted
Isoquinolines
Male
Membrane Glycoproteins - metabolism
Membrane Transport Proteins
Mesencephalon - growth & development
Mesencephalon - metabolism
Midbrain
Middle Aged
Nerve Tissue Proteins
Positron emission tomography
Serotonin Antagonists
Serotonin Plasma Membrane Transport Proteins
Serotonin transporter
Thalamus
Thalamus - growth & development
Thalamus - metabolism
Tomography, Emission-Computed
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Summary:There is growing interest in serotonin transporter (5-HTT) function in the human brain, since alteration in 5-HTT has been suggested in a variety of neurophychiatric disorders. Age-related decline in postsynaptic 5-HT receptors has been demonstrated in postmortem human studies and in vivo imaging studies, and has been assumed to be related to changes in mental function in the normal aging process. However, few studies have investigated the aging effect on 5-HTT in human brain in vivo, since the availability of suitable ligands has been limited. To investigate the aging effect on 5-HTT in living human brain, we performed positron emission tomography (PET) scans with a selective ligand for 5-HTT, [ 11C](+)McN5652. We examined 28 healthy male volunteers aged between 20 and 79 years. The uptake was quantified in the thalamus and midbrain by graphical analysis with the cerebellum as a reference tissue, and binding potential (BP) was used for the index of 5-HTT binding. There was a significant age-related decline in BP in the thalamus and midbrain. The decline in [ 11C](+)McN5652 binding was 9.6% per decade in the thalamus and 10.5% per decade in the midbrain.
ISSN:0024-3205
1879-0631
DOI:10.1016/S0024-3205(02)01745-9