Meningioma Pathology, Genetics, and Biology

Over the past 5 to 10 years, important advances were made in the understanding of meningioma biology. Progress in molecular genetics probably represents the most important accomplishment in the comprehensive knowledge of meningioma pathogenesis. Several genes could be identified as targets for mutat...

Full description

Saved in:
Bibliographic Details
Published in:Journal of neuropathology and experimental neurology 2004-04, Vol.63 (4), p.275-286
Main Author: LAMSZUS, KATRIN
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Female
Genetics
Humans
Male
Medical sciences
Meningeal Neoplasms - classification
Meningeal Neoplasms - genetics
Meningeal Neoplasms - pathology
Meningioma - classification
Meningioma - genetics
Meningioma - pathology
Mutation
Neovascularization, Pathologic
Neurology
Prognosis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Over the past 5 to 10 years, important advances were made in the understanding of meningioma biology. Progress in molecular genetics probably represents the most important accomplishment in the comprehensive knowledge of meningioma pathogenesis. Several genes could be identified as targets for mutation or inactivation. Additional chromosomal regions were found to be commonly deleted or amplified, suggesting the presence of further tumor suppressor genes or proto-oncogenes, respectively, in these regions. Histopathologically, the most important innovation is represented by the revised WHO classification in the year 2000. Meningioma grading criteria in the new classification scheme are more precise and objective, and should thus improve consistency in predicting tumor recurrence and aggressive behavior. This review focuses mainly on the advances in molecular biology that were achieved in recent years. It summarizes the most important aspects of meningioma classification as the basis to place biological observations into a correlative context, and, further, includes mechanisms of angiogenesis and edema formation as well as the role of hormone receptors in meningiomas.
ISSN:0022-3069
1554-6578
DOI:10.1093/jnen/63.4.275