Keratoacanthoma as a postoperative complication of skin cancer excision

Keratoacanthomas usually occur spontaneously as a single rapidly growing tumor on sun-exposed skin. Multiple keratoacanthomas are rarely seen. Keratoacanthomas may also develop after trauma, laser resurfacing, radiation therapy, and at the donor site after skin grafting. We report 6 cases of keratoa...

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Bibliographic Details
Published in:Journal of the American Academy of Dermatology 2004-05, Vol.50 (5), p.753-758
Main Authors: Goldberg, Leonard H, Silapunt, Sirunya, Beyrau, Kathleen K, Peterson, S.Ray, Friedman, Paul M, Alam, Murad
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Carcinoma, Basal Cell - surgery
Carcinoma, Squamous Cell - surgery
Dermatology
Female
Humans
Hutchinson's Melanotic Freckle - surgery
Keratoacanthoma - etiology
Keratoacanthoma - pathology
Keratoacanthoma - surgery
Male
Medical sciences
Mohs Surgery - adverse effects
Recurrence
Skin Neoplasms - surgery
Tumors of the skin and soft tissue. Premalignant lesions
Wound Healing
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Summary:Keratoacanthomas usually occur spontaneously as a single rapidly growing tumor on sun-exposed skin. Multiple keratoacanthomas are rarely seen. Keratoacanthomas may also develop after trauma, laser resurfacing, radiation therapy, and at the donor site after skin grafting. We report 6 cases of keratoacanthomas that developed in and around healing and healed surgical sites after treatment of skin cancer. These tumors developed 1 to 3 months after surgery and were sometimes multiple. We performed follow-up examinations of patients' wounds after the treatment of skin cancer. Histological examination of nodules developing in the margins of healing wound sites and in the scars of healed wound sites after Mohs micrographic surgery revealed keratoacanthomas. The tumors presented as a rapidly growing nodule or nodules, with the typical morphology and pathology of keratoacanthoma. One patient developed multiple keratoacanthomas at surgical and nonsurgical sites. These nodules were treated by a combination of excision, curettage and electrodesiccation, and oral isotretinoin, 4 mg/d. Keratoacanthoma must be considered in the differential diagnosis of a rapidly growing nodule within or around the surgical site after skin cancer surgery.
ISSN:0190-9622
1097-6787
DOI:10.1016/j.jaad.2003.11.065