Liver transplantation from maastricht category 2 non–heart-beating donors: a source to increase the donor pool?

The demand for liver transplantation has increasingly exceeded the supply of cadaver donor organs. Non–heart-beating donors (NHBDs) may be an alternative to increase the cadaver donor pool. The outcome of 20 liver transplants from Maastricht category 2 NHBD was compared with that of 40 liver transpl...

Full description

Saved in:
Bibliographic Details
Published in:Transplantation proceedings 2004-04, Vol.36 (3), p.747-750
Main Authors: Otero, A, Gómez-Gutiérrez, M, Suárez, F, Arnal, F, Fernández-García, A, Aguirrezabalaga, J, García-Buitrón, J, Alvarez, J, Máñez, R
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Cardiopulmonary Resuscitation
Follow-Up Studies
Graft Survival
Heart Arrest
Heart Rate
Hepatectomy - methods
Humans
Liver - cytology
Liver - pathology
Liver Transplantation - mortality
Liver Transplantation - physiology
Liver, biliary tract, pancreas, portal circulation, spleen
Medical sciences
Middle Aged
Retrospective Studies
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the digestive system
Survival Analysis
Time Factors
Tissue and Organ Harvesting - methods
Tissue Donors - classification
Tissue Donors - supply & distribution
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The demand for liver transplantation has increasingly exceeded the supply of cadaver donor organs. Non–heart-beating donors (NHBDs) may be an alternative to increase the cadaver donor pool. The outcome of 20 liver transplants from Maastricht category 2 NHBD was compared with that of 40 liver transplants from heart-beating donors (HBDs). After unsuccessful cardiopulmonary resuscitation (CPR), cardiopulmonary support with simultaneous application of chest and abdominal compression (CPS; n = 6) or cardiopulmonary bypass (CPB; n = 14) was used to maintain the donors. At a minimum follow-up of 2 years, actuarial patient and graft survival rates with livers from Maastricht category 2 NHBD were 80% and 55%, respectively. Transplantation of organs from these donors was associated with a significantly higher incidence of primary nonfunction, biliary complications, and more severe initial liver dysfunction compared with organs from HBDs. The graft survival rates was 83% for livers from NHBDs preserved with CPS and 42% in those maintained with CPB.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2004.03.027