Plasmodium falciparum-induced channels

To survive within a red blood cell, the malaria parasite alters dramatically the permeability of the host's plasma membrane (allowing the uptake of essential nutrients and the removal of potentially hazardous metabolites). The pathway(s) responsible for the increased permeability have been prop...

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Bibliographic Details
Published in:International Journal for Parasitology 2004-05, Vol.34 (6), p.665-673
Main Authors: Staines, Henry M, Powell, Trevor, Thomas, Serge L.Y, Clive Ellory, J
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cell Membrane - parasitology
Cell Membrane Permeability - physiology
Channel
Electrophysiology
Erythrocyte
Erythrocytes - parasitology
Fundamental and applied biological sciences. Psychology
Host-Parasite Interactions - physiology
Human protozoal diseases
Humans
Infectious diseases
Ion Channels - physiology
Life cycle. Host-agent relationship. Pathogenesis
Malaria
Malaria, Falciparum - physiopathology
Malaria, Falciparum - prevention & control
Medical sciences
Membrane transport
Models, Biological
Parasitic diseases
Plasmodium falciparum
Plasmodium falciparum - physiology
Protozoa
Protozoal diseases
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Summary:To survive within a red blood cell, the malaria parasite alters dramatically the permeability of the host's plasma membrane (allowing the uptake of essential nutrients and the removal of potentially hazardous metabolites). The pathway(s) responsible for the increased permeability have been proposed as putative chemotherapeutic targets and/or selective routes for antimalarial agents that target the internal parasite. This review covers our current understanding of this parasite-induced phenomenon in Plasmodium falciparum-infected human red blood cells. In particular, recent electrophysiological studies, using the patch-clamp technique, are reviewed.
ISSN:0020-7519
1879-0135
DOI:10.1016/j.ijpara.2004.02.007