CYP3A4-V and prostate cancer in African Americans: causal or confounding association because of population stratification?

CYP3A4-V, an A to G promoter variant associated with prostate cancer in African Americans, exhibits large differences in allele frequency between populations. Given that the African American population is genetically heterogeneous because of its African ancestry and subsequent admixture with Europea...

Full description

Saved in:
Bibliographic Details
Published in:Human genetics 2002-06, Vol.110 (6), p.553-560
Main Authors: KITTLES, Rick A, WEIDONG CHEN, KWAGYAN, John, ISAACS, William, FREEMAN, Vincent, DUNSTON, Georgia M, PANGULURI, Ramesh K, AHAGHOTU, Chiledum, JACKSON, Aaron, ADEBAMOWO, Clement A, GRIFFIN, Robin, WILLIAMS, Tyisha, UKOLI, Flora, ADAMS-CAMPBELL, Lucile
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Alleles
Base Sequence
Biological and medical sciences
Black or African American
Black People - genetics
Case-Control Studies
Cell physiology
Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme System - genetics
DNA, Neoplasm - genetics
Fundamental and applied biological sciences. Psychology
Gene Frequency
Genetic Markers
Genetic Variation
Humans
Male
Middle Aged
Mixed Function Oxygenases - genetics
Molecular and cellular biology
Nigeria
Promoter Regions, Genetic
Prostatic Neoplasms - genetics
United States
White People - genetics
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:CYP3A4-V, an A to G promoter variant associated with prostate cancer in African Americans, exhibits large differences in allele frequency between populations. Given that the African American population is genetically heterogeneous because of its African ancestry and subsequent admixture with European Americans, case-control studies with African Americans are highly susceptible to spurious associations. To test for association with prostate cancer, we genotyped CYP3A4-V in 1376 (2 N) chromosomes from prostate cancer patients and age- and ethnicity-matched controls representing African Americans, Nigerians, and European Americans. To detect population stratification among the African American samples, 10 unlinked genetic markers were genotyped. To correct for the stratification, the uncorrected association statistic was divided by the average of association statistics across the 10 unlinked markers. Sharp differences in CYP3A4-V frequencies were observed between Nigerian and European American controls (0.87 and 0.10, respectively; P
ISSN:0340-6717
1432-1203
DOI:10.1007/s00439-002-0731-5