Procalcitonin as a marker of acute pyelonephritis in infants and children

In the absence of specific symptomatology in children, the early diagnosis of acute pyelonephritis is a challenge, particularly during infancy. In an attempt to differentiate acute pyelonephritis from lower urinary tract infection (UTI), we measured serum procalcitonin (PCT) levels and compared thes...

Full description

Saved in:
Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 2002-06, Vol.17 (6), p.409-412
Main Authors: SMOLKIN, Vladislav, KOREN, Ariel, RAZ, Raul, COLODNER, Raul, SAKRAN, Waheeb, HALEVY, Raphael
Format: Article
Language:English
Subjects:
Acute Disease
Biological and medical sciences
Biomarkers - blood
C-Reactive Protein - analysis
Calcitonin - blood
Calcitonin Gene-Related Peptide
Child, Preschool
Diagnosis, Differential
Escherichia coli Infections - diagnosis
Female
Humans
Infant
Infant, Newborn
Kidney - diagnostic imaging
Kidneys
Leukocyte Count
Leukocytes
Male
Medical sciences
Nephrology. Urinary tract diseases
Pediatrics
Prognosis
Prospective Studies
Protein Precursors - blood
Proteins
Pyelonephritis - blood
Pyelonephritis - diagnosis
Pyelonephritis - diagnostic imaging
Radionuclide Imaging
Scintigraphy
Sensitivity and Specificity
Succimer
Urinary system involvement in other diseases. Miscellaneous
Urinary tract diseases
Urinary tract infections
Urinary Tract Infections - diagnosis
Urogenital system
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In the absence of specific symptomatology in children, the early diagnosis of acute pyelonephritis is a challenge, particularly during infancy. In an attempt to differentiate acute pyelonephritis from lower urinary tract infection (UTI), we measured serum procalcitonin (PCT) levels and compared these with other commonly used inflammatory markers. We evaluated the ability of serum PCT levels to predict renal involvement, as assessed by dimercaptosuccinic acid (DMSA) scintigraphy. Serum C-reactive protein (CRP), leukocyte counts, and PCT levels were measured in 64 children admitted for suspected UTI. Renal parenchymal involvement was assessed by (99m)Tc-DMSA scintigraphy in the first 7 days after admission. In acute pyelonephritis, the median PCT level was significantly higher than in the lower UTI group (3.41, range 0.36-12.4 microg/l vs. 0.13, range 0.02-2.15 microg/l, P
ISSN:0931-041X
1432-198X
DOI:10.1007/s00467-001-0790-1