Does PTH have a direct effect on intestine?

Dogma for the past three decades has dictated that parathyroid hormone (PTH) has no direct effect on intestine with regard to calcium or phosphate absorption, but rather that PTH acts to promote the synthesis of a hormonally active form of vitamin D, namely 1,25‐dihydroxyvitamin D3 [1,25(OH)2D3]. Ho...

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Bibliographic Details
Published in:Journal of cellular biochemistry 2002, Vol.86 (1), p.29-34
Main Authors: Nemere, I., Larsson, D.
Format: Article
Language:English
Subjects:
Animals
calcium
Calcium - metabolism
enterocytes
Humans
Intestinal Absorption - drug effects
Intestines - drug effects
Intestines - metabolism
Ion Transport - drug effects
Parathyroid Hormone - metabolism
Parathyroid Hormone - pharmacology
phosphate
receptors
Receptors, Parathyroid Hormone - genetics
Receptors, Parathyroid Hormone - metabolism
signal transduction
Signal Transduction - drug effects
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Summary:Dogma for the past three decades has dictated that parathyroid hormone (PTH) has no direct effect on intestine with regard to calcium or phosphate absorption, but rather that PTH acts to promote the synthesis of a hormonally active form of vitamin D, namely 1,25‐dihydroxyvitamin D3 [1,25(OH)2D3]. However, diverse laboratories have each provided some evidence to suggest PTH does indeed have a direct effect on intestine. We will briefly review the evidence for biological effects, biochemical effects, and the presence of intestinal receptors for PTH, and conclude with the implications for biomedical research. J. Cell. Biochem. 86: 29–34, 2002. © 2002 Wiley‐Liss, Inc.
ISSN:0730-2312
1097-4644
DOI:10.1002/jcb.10199