Biermer's disease and venous thrombosis. Report of two cases

The main issue in venous thrombotic events is their etiology. Several clinical and/or biological data can be helpful in that research. In the two cases we report here, a macrocytic anemia led to the diagnosis of probably acquired hyperhomocysteinemia. a 24-year-old man was admitted for severe anemia...

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Bibliographic Details
Published in:La revue de medecine interne 2002-06, Vol.23 (6), p.563-566
Main Authors: Kharchafi, A, Oualim, Z, Amezyane, T, Mahassin, F, Ghafir, D, Ohayon, V, Archane, M I
Format: Article
Language:fre
Subjects:
Adult
Anemia, Pernicious - complications
Anemia, Pernicious - diagnosis
Humans
Hyperhomocysteinemia - complications
Hyperhomocysteinemia - etiology
Injections, Subcutaneous
Male
Risk Factors
Venous Thrombosis - etiology
Vitamin B 12 - therapeutic use
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Summary:The main issue in venous thrombotic events is their etiology. Several clinical and/or biological data can be helpful in that research. In the two cases we report here, a macrocytic anemia led to the diagnosis of probably acquired hyperhomocysteinemia. a 24-year-old man was admitted for severe anemia and a superior vena cava syndrome. Biological data showed megaloblastic anemia and mild features of blood destruction that were explained by a pernicious anemia. Second case: a 35-year-old man had two deep venous thrombotic events in one year (involving the right leg, then the left leg); biological findings showed a macrocytic mild anemia that was diagnosed as a pernicious anemia. In both of the patients, deep venous thrombosis was mainly explained by a hyperhomocysteinemia that was a consequence of vitamin B12 deficiency. The two patients improved under anticoagulant treatment combined with subcutaneous vitamin B12. Pernicious anemia can cause acquired hyperhomocysteinemia, which is considered a risk factor for deep venous thrombosis. Thus, the connectivity of these conditions should remain in the practitioner's mind, especially when thrombosis occurs along with a macrocytic anemia.
ISSN:0248-8663