Fusarium Infection in Hematopoietic Stem Cell Transplant Recipients

To characterize the epidemiology and prognostic factors of invasive fusariosis in hematopoietic stem cell transplant (HSCT) recipients, the records of HSCT recipients from 9 hospitals (7 in Brazil and 2 in the United States) were retrospectively reviewed. Sixty-one cases were identified: 54 in allog...

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Bibliographic Details
Published in:Clinical infectious diseases 2004-05, Vol.38 (9), p.1237-1242
Main Authors: Nucci, Marcio, Marr, Kieren A., Queiroz-Telles, Flavio, Martins, Carlos A., Trabasso, Plínio, Costa, Silvia, Voltarelli, Julio C., Colombo, Arnaldo L., Imhof, Alexander, Pasquini, Ricardo, Maiolino, Angelo, Cármino, A. Souza, Anaissie, Elias
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aspergillosis
Biological and medical sciences
Blood
Brazil - epidemiology
Child
Child, Preschool
Female
Fusariosis
Fusarium
Graft vs host disease
Hematologic and hematopoietic diseases
Hematopoietic Stem Cell Transplantation - adverse effects
Hematopoietic stem cells
Humans
Infections
Major Articles
Male
Medical sciences
Middle Aged
Mud
Mycoses - epidemiology
Mycoses - etiology
Mycoses - microbiology
Neutropenia
Opportunistic Infections - epidemiology
Opportunistic Infections - etiology
Other diseases. Hematologic involvement in other diseases
Transplantation
United States - epidemiology
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Summary:To characterize the epidemiology and prognostic factors of invasive fusariosis in hematopoietic stem cell transplant (HSCT) recipients, the records of HSCT recipients from 9 hospitals (7 in Brazil and 2 in the United States) were retrospectively reviewed. Sixty-one cases were identified: 54 in allogeneic HSCT recipients and 7 in autologous HSCT recipients. The incidence of fusariosis among allogeneic HSCT recipients varied between a range of 4.21-5.0 cases per 1000 in human leukocyte antigen (HLA)-matched related transplant recipients to 20.19 cases per 1000 in HLA-mismatched transplant recipients. The median time period between transplantation and diagnosis of fusariosis was 48 days. Among allogeneic HSCT recipients, a trimodal distribution was observed: a first peak before engraftment, a second peak at a median of 62 days after transplantation, and a third peak >1 year after transplantation. The actuarial survival was 13% (median, 13 days). Persistent neutropenia was the single prognostic factor for death identified by multivariate analysis.
ISSN:1058-4838
1537-6591
DOI:10.1086/383319