The relation between latent inhibition and symptom-types in young schizophrenics

Latent inhibition (LI), retarded conditioning to a stimulus that has been previously repeatedly presented without reinforcement, was examined in young schizophrenics and normal controls using a within-subject visual search task. Healthy controls exhibited the usual LI effect. LI was potentiated in s...

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Bibliographic Details
Published in:Behavioural brain research 2004-03, Vol.149 (2), p.113-122
Main Authors: Cohen, Efrat, Sereni, Noam, Kaplan, O, Weizman, A, Kikinzon, L, Weiner, I, Lubow, R.E
Format: Article
Language:English
Subjects:
Adolescent
Adult
Adult and adolescent clinical studies
Analysis of Variance
Attention
Biological and medical sciences
Female
Hospitalization - statistics & numerical data
Humans
Inhibition (Psychology)
Latent inhibition
Male
Medical sciences
Negative symptoms
Positive symptoms
Psychiatric Status Rating Scales
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Reaction Time - physiology
Schizophrenia
Schizophrenia - physiopathology
Schizophrenic Psychology
Task Performance and Analysis
Visual Perception - physiology
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Summary:Latent inhibition (LI), retarded conditioning to a stimulus that has been previously repeatedly presented without reinforcement, was examined in young schizophrenics and normal controls using a within-subject visual search task. Healthy controls exhibited the usual LI effect. LI was potentiated in schizophrenics who simultaneously exhibited high levels of negative symptoms and low levels of positive symptoms. Schizophrenic groups with other combinations of positive and negative symptoms did not differ from controls. The pattern of data suggests that past inconsistencies in the LI-schizophrenia literature may be the result of opposing processes that are associated with positive and negative symptoms.
ISSN:0166-4328
1872-7549
DOI:10.1016/S0166-4328(03)00221-3