Fibrinolytic administration for acute myocardial infarction in a tertiary ED: factors associated with an increased door-to-needle time

• Published in: The American journal of emergency medicine 2004-05, Vol.22 (3), p.192-196
• Main Authors: Zed, Peter J., Abu-Laban, Riyad B., Cadieu, Travis M., Purssell, Roy A., Filiatrault, Lyne
• Format: Article
• Language: English
• Subjects: Aged; Analysis of Variance; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Angina pectoris; Bats; Biological and medical sciences; British Columbia; door-to-needle time; Efficiency, Organizational; Electrocardiography; emergency department; Emergency medical care; Emergency Service, Hospital - organization & administration; Emergency Treatment - methods; Emergency Treatment - standards; Emergency Treatment - statistics & numerical data; Female; fibrinolytic; Guideline Adherence - standards; Health Services Research; Heart attacks; Hospitals, General; Humans; Intensive care medicine; Length of Stay - statistics & numerical data; Linear Models; Male; Medical Audit; Medical prognosis; Medical sciences; Middle Aged; Mortality; Myocardial infarction; Myocardial Infarction - diagnosis; Myocardial Infarction - drug therapy; Patients; Practice Guidelines as Topic; Practice Patterns, Physicians' - organization & administration; Retrospective Studies; Thrombolytic; Thrombolytic Therapy - methods; Thrombolytic Therapy - standards; Thrombolytic Therapy - statistics & numerical data; Time Factors; Treatment Outcome
• ISSN: 0735-6757; 1532-8171
• DOI: 10.1016/j.ajem.2004.02.005

The purpose of this study was to evaluate the door-to-needle time for fibrinolytic administration for acute myocardial infarction (AMI) at Vancouver General Hospital (VGH) and identify factors associated with time prolongation. A retrospective chart review of all patients fibrinolysed for AMI in the ED at VGH was performed from January 1, 1998, to December 31, 1999, to determine door-to-needle time. A mixed-effects linear regression model was fit to the fibrinolytic data with the door-to-needle time to identify factors associated with prolonged times. One hundred forty patients were included in the final analysis. The mean and median door-to-needle times were 58 and 43 minutes, respectively. A door-to-needle time of under 30 minutes was achieved in 24.3% of patients, 30 to 40 minutes in 24.3%, 40 to 60 minutes in 22.1%, and over 60 minutes in 29.3%. EP prescribers without prior cardiologist consultation resulted in a significantly shorter door-to-needle time compared with requesting a cardiology consult before administration (mean [median] 41 [35] minutes vs. 108 [90] minutes respectively; P < .001). Patients who arrived by ambulance had shorter door-to-needle times than those who did not (mean [median] 50 [38] minutes vs. 71 [57] minutes, respectively; P = .008). Patients who arrived during the night shift (2300–0700 hrs) had significantly shorter door-to-needle times than those patients who arrived during the day (0700–1500 hrs) or afternoon (1500–2300) shifts ( P = 0481); and patients who had a longer time from chest pain onset to ED arrival also had longer door-to-needle times ( P = .0233). A significant number of AMI patients fibrinolysed at VGH do not meet the national guideline for door-to-needle time less than 30 minutes. Factors associated with this should be addressed to improve the care of patients with AMI.