Green banana and pectin improve small intestinal permeability and reduce fluid loss in bangladeshi children with persistent diarrhea

To evaluate the effects of green banana and pectin (nondigestible, dietary sources of colonic shortchain fatty acids [SCFA]) on intestinal permeability, 57 boys (5-12 months) with persistent diarrhea (> or = 14 days) were given a week's treatment with a rice-based diet containing either cook...

Full description

Saved in:
Bibliographic Details
Published in:Digestive diseases and sciences 2004-03, Vol.49 (3), p.475-484
Main Authors: RABBANI, G. H, TEKA, Telahun, SHYAMAL KUMAR SAHA, ZAMAN, Badiuz, MAJID, Naseha, KHATUN, Makhduma, WAHED, Mohammad A, FUCHS, George J
Format: Article
Language:English
Subjects:
Antidiarrheals - administration & dosage
Bangladesh
Biological and medical sciences
Diarrhea, Infantile - diet therapy
Diarrhea, Infantile - physiopathology
Feeding. Feeding behavior
Fundamental and applied biological sciences. Psychology
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Infant
Intestinal Absorption - drug effects
Intestinal Mucosa - metabolism
Lactulose - urine
Male
Mannitol - urine
Medical sciences
Metabolic diseases
Musa
Oryza
Pectins - administration & dosage
Permeability
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To evaluate the effects of green banana and pectin (nondigestible, dietary sources of colonic shortchain fatty acids [SCFA]) on intestinal permeability, 57 boys (5-12 months) with persistent diarrhea (> or = 14 days) were given a week's treatment with a rice-based diet containing either cooked green banana (n = 19), pectin (n = 17), or rice diet alone (n = 21). Intestinal permeability was assessed before and after treatment by giving a lactulose-mannitol (LM) drink and measuring urinary recovery after 5 hr. Treatment with banana significantly (P < 0.05) reduced lactulose recovery, increased mannitol recovery, and decreased the LM ratio, indicating improvement of permeability. Pectin produced similar results. Permeability changes were associated with a 50% reduction in stool weights which correlated strongly (green banana, r2 = 0.84, pectin, r2 = 0.86) with the LM ratio. Green banana-derived and SCFA-mediated stimulation of colonic as well as small bowel absorption is responsible for their antidiarrheal effects. The antidiarrheal effects of green banana and pectin are mediated by improvement of small intestinal permeability in addition to their known colonotrophic effects.
ISSN:0163-2116
1573-2568
DOI:10.1023/B:DDAS.0000020507.25910.cf