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CMV and blood transfusions
Among the human herpesviruses, cytomegalovirus (CMV) is the only one that has assumed significant importance in blood transfusion. Transfusion transmission of CMV (TT‐CMV) to seronegative immunocompromised patients can lead to lethal CMV disease. Studies over the past 30 years have demonstrated that...
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Published in: | Reviews in medical virology 2002-07, Vol.12 (4), p.211-219 |
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description | Among the human herpesviruses, cytomegalovirus (CMV) is the only one that has assumed significant importance in blood transfusion. Transfusion transmission of CMV (TT‐CMV) to seronegative immunocompromised patients can lead to lethal CMV disease. Studies over the past 30 years have demonstrated that monocytes latently infected with CMV represent the primary vector for TT‐CMV, and that TT‐CMV can be largely abrogated by transfusing at‐risk patients with either seronegative units or blood filtered to remove white blood cells. However, the small number of cases of breakthrough TT‐CMV that follow transfusion of either seronegative or filtered blood still produce morbidity and mortality. These circumstances have motivated ongoing efforts to provide improved protection from TT‐CMV, including the use of CMV DNA amplification for blood screening, and pathogen inactivation to sterilise all blood components prior to transfusion. Copyright © 2002 John Wiley & Sons, Ltd. |
doi_str_mv | 10.1002/rmv.353 |
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Transfusion transmission of CMV (TT‐CMV) to seronegative immunocompromised patients can lead to lethal CMV disease. Studies over the past 30 years have demonstrated that monocytes latently infected with CMV represent the primary vector for TT‐CMV, and that TT‐CMV can be largely abrogated by transfusing at‐risk patients with either seronegative units or blood filtered to remove white blood cells. However, the small number of cases of breakthrough TT‐CMV that follow transfusion of either seronegative or filtered blood still produce morbidity and mortality. These circumstances have motivated ongoing efforts to provide improved protection from TT‐CMV, including the use of CMV DNA amplification for blood screening, and pathogen inactivation to sterilise all blood components prior to transfusion. Copyright © 2002 John Wiley & Sons, Ltd.</description><identifier>ISSN: 1052-9276</identifier><identifier>EISSN: 1099-1654</identifier><identifier>DOI: 10.1002/rmv.353</identifier><identifier>PMID: 12125013</identifier><identifier>CODEN: RMVIEW</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Adult ; Biological and medical sciences ; Child ; Child, Preschool ; Cytomegalovirus - isolation & purification ; Cytomegalovirus Infections - diagnosis ; Cytomegalovirus Infections - prevention & control ; Cytomegalovirus Infections - transmission ; Disinfection - methods ; DNA, Viral - analysis ; Female ; Human viral diseases ; Humans ; Infant, Newborn ; Infectious diseases ; Medical sciences ; Miscellaneous ; Polymerase Chain Reaction ; Pregnancy ; Risk Factors ; Transfusion Reaction ; Viral diseases</subject><ispartof>Reviews in medical virology, 2002-07, Vol.12 (4), p.211-219</ispartof><rights>Copyright © 2002 John Wiley & Sons, Ltd.</rights><rights>2002 INIST-CNRS</rights><rights>Copyright 2002 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5053-53ffb3b8c8cf40dd516fb941f2d87c6c50d6d649dbb47c8c40dd27aac90f041e3</citedby><cites>FETCH-LOGICAL-c5053-53ffb3b8c8cf40dd516fb941f2d87c6c50d6d649dbb47c8c40dd27aac90f041e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13790091$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12125013$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roback, John D.</creatorcontrib><title>CMV and blood transfusions</title><title>Reviews in medical virology</title><addtitle>Rev. 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subjects | Adult Biological and medical sciences Child Child, Preschool Cytomegalovirus - isolation & purification Cytomegalovirus Infections - diagnosis Cytomegalovirus Infections - prevention & control Cytomegalovirus Infections - transmission Disinfection - methods DNA, Viral - analysis Female Human viral diseases Humans Infant, Newborn Infectious diseases Medical sciences Miscellaneous Polymerase Chain Reaction Pregnancy Risk Factors Transfusion Reaction Viral diseases |
title | CMV and blood transfusions |
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