Relatively low levels of calpain expression in juvenile rat correlate with less neuronal apoptosis after spinal cord injury

Approximately 5% of spinal cord injuries in the US occur in patients younger than 16 years. These young patients have an increased mortality within the 24 h after trauma but have a greater capacity for functional recovery than adults, suggesting age-related differences in injury tolerance. Unfortuna...

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Bibliographic Details
Published in:Experimental neurology 2004-06, Vol.187 (2), p.529-532
Main Authors: Wingrave, J.M., Sribnick, E.A., Wilford, G.G., Matzelle, D.D., Mou, J.A., Ray, S.K., Hogan, E.L., Banik, N.L.
Format: Article
Language:English
Subjects:
Age Factors
Animals
Apoptosis
Biological and medical sciences
Calpain
Calpain - biosynthesis
Calpastatin
Cell Count
Cell death
Disease Models, Animal
Disease Progression
Female
Fluorescent Antibody Technique
Immunohistochemistry
In Situ Nick-End Labeling
Injuries of the nervous system and the skull. Diseases due to physical agents
Juvenile
Medical sciences
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Neurology
Neuronal apoptosis
Neurons - enzymology
Neurons - pathology
Rats
Rats, Sprague-Dawley
Secondary injury
Spinal Cord Injuries - enzymology
Spinal Cord Injuries - pathology
Spinal cord injury
Traumas. Diseases due to physical agents
Up-Regulation
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Description
Summary:Approximately 5% of spinal cord injuries in the US occur in patients younger than 16 years. These young patients have an increased mortality within the 24 h after trauma but have a greater capacity for functional recovery than adults, suggesting age-related differences in injury tolerance. Unfortunately, the response of the developing cord to secondary injury has not been thoroughly investigated. Calpain, a Ca 2+-dependent protease, has been implicated in the pathogenesis of spinal cord injury (SCI) in rats. Our current investigation revealed that following SCI, calpain upregulation was qualitatively less in the 21-day-old rats than in adult rats, as shown by immunofluorescent labeling. Decreased levels of TUNEL+ neurons were also noted in juvenile rat spinal cord, indicating that the developing cord may have an increased resistance to injury.
ISSN:0014-4886
1090-2430
DOI:10.1016/j.expneurol.2004.02.001