On-pump versus off-pump coronary artery bypass grafting: more heat-shock protein 70 is released after on-pump surgery

Objectives: The use of cardiopulmonary bypass in coronary artery bypass grafting (CABG) may contribute to the postoperative inflammatory response. The molecular chaperone heat-shock protein (HSP) 70 may be induced by ischemia, and has been detected both in the myocardium and in the circulation after...

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Bibliographic Details
Published in:European journal of cardio-thoracic surgery 2004-06, Vol.25 (6), p.985-992
Main Authors: Dybdahl, Brit, Wahba, Alexander, Haaverstad, Rune, Kirkeby-Garstad, Idar, Kierulf, Peter, Espevik, Terje, Sundan, Anders
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Biomarkers - blood
Cardiopulmonary Bypass - adverse effects
Cell-signaling proteins
Coronary Artery Bypass - methods
Coronary artery bypass surgery
Creatine Kinase - blood
Creatine Kinase, MB Form
Female
Heat-shock proteins
Hemoglobins - metabolism
HSP70 Heat-Shock Proteins - blood
Humans
Immunology
Interleukins - blood
Ischemia/reperfusion
Isoenzymes - blood
Male
Medical sciences
Middle Aged
Myocardial Ischemia - blood
Myocardial Ischemia - etiology
Off-pump
Postoperative Period
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the heart
Troponin T - blood
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Summary:Objectives: The use of cardiopulmonary bypass in coronary artery bypass grafting (CABG) may contribute to the postoperative inflammatory response. The molecular chaperone heat-shock protein (HSP) 70 may be induced by ischemia, and has been detected both in the myocardium and in the circulation after CABG. In vitro, extracellular HSP70 may activate both innate and adaptive immunity. Hypothesizing that use of cardiopulmonary bypass (CPB) leads to more circulating HSP70, we explored the release of it in 10 patients undergoing CABG with the use of CPB, and in 10 patients undergoing off-pump surgery CABG (OPCAB). Methods: Blood samples were taken preoperatively, twice peroperatively, 2 and 6 h postoperatively and the next day. Serum analyses were performed by means of immunoassays. Results: We detected a significant difference in postoperative circulating HSP70 between on-pump and off-pump patients (median peaks of 2849 and 756 pg/ml, respectively, P
ISSN:1010-7940
1873-734X
DOI:10.1016/j.ejcts.2004.03.002