Selenium concentrations in maternal and umbilical cord blood at 24–42 weeks of gestation: basis for optimization of selenium supplementation to premature infants

Background & Aims: Selenium (Se) deficiency may have deleterious effects on premature infants. Umbilical cord (UC) Se concentrations presumably reflect fetal Se concentrations and represent reference values that should be achieved in premature infants. We aimed to establish reference data of Se...

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Bibliographic Details
Published in:Clinical nutrition (Edinburgh, Scotland) Scotland), 2004-06, Vol.23 (3), p.373-381
Main Authors: Makhoul, Imad R, Sammour, Rami N, Diamond, Eric, Shohat, Irit, Tamir, Ada, Shamir, Raanan
Format: Article
Language:English
Subjects:
Adult
Antioxidants - metabolism
Biological and medical sciences
Birth Weight - physiology
Diseases of mother, fetus and pregnancy
Female
Fetal Blood - chemistry
Gestation
Gestational Age
Gynecology. Andrology. Obstetrics
Humans
Infant, Newborn
Infant, Premature - blood
Medical sciences
Nutritional Requirements
Nutritional Status
Pregnancy - blood
Pregnancy Complications - blood
Pregnancy. Fetus. Placenta
Premature infant
Reference Values
Regression Analysis
Selenium
Selenium - administration & dosage
Selenium - blood
Selenium - deficiency
Serum
Spectrophotometry, Atomic - methods
Umbilical cord
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Summary:Background & Aims: Selenium (Se) deficiency may have deleterious effects on premature infants. Umbilical cord (UC) Se concentrations presumably reflect fetal Se concentrations and represent reference values that should be achieved in premature infants. We aimed to establish reference data of Se serum concentrations in parturient women and their neonates across gestation. Subjects and methods: Parturient mothers and their newborn infants born after 24–42 weeks of gestation were enrolled. Only appropriate for gestational age (GA) singleton infants were included. Se serum concentrations were measured by atomic absorption spectrometry, in blood samples from parturient mothers and their infants (umbilical blood). Demographic, perinatal and labor data were obtained, and their correlations with umbilical Se serum concentrations, maternal Se serum concentrations, and the maternal–umbilical Se difference were examined. Results: UC Se serum concentrations increased as gestation progressed ( P
ISSN:0261-5614
1532-1983
DOI:10.1016/j.clnu.2003.08.004