Delayed rises in serum S100B levels and adverse neurological outcome in infants and children undergoing cardiopulmonary bypass

Summary Background : The protein S100B is a marker of brain injury. Early after cardiopulmonary bypass (CPB), serum S100B levels are artefactually high. We investigated whether delayed (48 h) rise in S100B levels may have a role in detecting brain injury after CPB. Methods : Data from 43 children we...

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Bibliographic Details
Published in:Pediatric anesthesia 2004-06, Vol.14 (6), p.495-500
Main Authors: Lardner, David, Davidson, Andrew, McKenzie, Ian, Cochrane, Andrew
Format: Article
Language:English
Subjects:
Anesthesia
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Biomarkers - blood
Brain Diseases - diagnosis
Brain Diseases - etiology
Brain Injuries - blood
Brain Injuries - diagnosis
Brain Injuries - etiology
Cardiac Surgical Procedures - adverse effects
cardiopulmonary bypass
Cardiopulmonary Bypass - adverse effects
Child
Child, Preschool
congenital heart disease
Developmental Disabilities - diagnosis
Developmental Disabilities - etiology
Humans
Infant
Medical sciences
Nerve Growth Factors
neurological injury
S100 Calcium Binding Protein beta Subunit
S100 Proteins - blood
S100B
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Summary:Summary Background : The protein S100B is a marker of brain injury. Early after cardiopulmonary bypass (CPB), serum S100B levels are artefactually high. We investigated whether delayed (48 h) rise in S100B levels may have a role in detecting brain injury after CPB. Methods : Data from 43 children were analysed in this study. Samples were collected at preincision and 30 min, 24 and 48 h postbypass and then analysed by using a commercially available radioimmunoassay (Sangtec100). Charts were reviewed at 3–5 months for evidence of neurological injury. Results : S100B levels were high preoperatively in neonates and universally high immediately postbypass. In 36 children, samples were available for all time points. Compared with preoperative levels, rises occurred at both 24 and 48 h in three patients, only at 24 h in four patients and only at 48 h in three patients. Two patients had evidence of neurological injury. A rise at 48 h was associated with neurological injury (odds ratio 33.9, P 
ISSN:1155-5645
1460-9592
DOI:10.1111/j.1460-9592.2004.01230.x