Hepatitis A and B Vaccination Practices for Ambulatory Patients Infected with HIV

Few studies exist of adherence to guidelines for vaccination of persons infected with human immunodeficiency virus (HIV), especially in the era of highly active antiretroviral therapy (HAART). In a retrospective, cross-sectional analysis in the HIV Outpatient Study sites, 198 (32.4%) of 612 patients...

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Bibliographic Details
Published in:Clinical infectious diseases 2004-05, Vol.38 (10), p.1478-1484
Main Authors: Tedaldi, Ellen M., Baker, Rose K., Moorman, Anne C., Wood, Kathleen C., Fuhrer, Jack, McCabe, Robert E., Holmberg, Scott D.
Format: Article
Language:English
Subjects:
Adult
AIDS
Antibodies
Biological and medical sciences
CD4 Lymphocyte Count
Female
Hepatitis A
Hepatitis A Vaccines - administration & dosage
Hepatitis A Vaccines - immunology
Hepatitis B
Hepatitis B Vaccines - administration & dosage
Hepatitis B Vaccines - immunology
Hepatitis B virus
Highly active antiretroviral therapy
HIV
HIV - genetics
HIV - physiology
HIV Infections - immunology
HIV Infections - virology
HIV/AIDS
Human viral diseases
Humans
Infections
Infectious diseases
Male
Medical sciences
Men
Middle Aged
RNA, Viral - analysis
Vaccination
Viral diseases
Viral diseases of the digestive system
Viral hepatitis
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Summary:Few studies exist of adherence to guidelines for vaccination of persons infected with human immunodeficiency virus (HIV), especially in the era of highly active antiretroviral therapy (HAART). In a retrospective, cross-sectional analysis in the HIV Outpatient Study sites, 198 (32.4%) of 612 patients eligible for hepatitis B vaccine received at least 1 dose. In multivariate analysis, hepatitis B vaccination was associated with HIV risk category, education level, and number of visits to the HIV clinic per year. Among 716 patients eligible for hepatitis A vaccine, 167 (23.3%) received ⩾1 dose. Response to hepatitis B vaccination was associated with higher nadir CD4+ cell counts (P = .008) and HIV RNA levels less than the level of detection (P = .04), although some response was documented at all CD4+ levels. Although there were low rates of complete hepatitis vaccination in this cohort of ambulatory patients, prompt efforts to vaccinate patients entering care, receipt of antiretroviral therapy, and practice reminder systems may enhance vaccination practices.
ISSN:1058-4838
1537-6591
DOI:10.1086/420740