Loading…

A potential antitumor peptide therapeutic derived from antineoplastic urinary protein

New therapies in cancer treatment are focusing on multifaceted approaches to starve and kill tumors utilizing both antiangiogenic and chemotherapeutic compounds. Antineoplastic Urinary Protein (ANUP), a 32 kDa protein normally secreted in human urine, has been previously described as a molecule poss...

Full description

Saved in:
Bibliographic Details
Published in:Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2004-04, Vol.25 (4), p.543-549
Main Authors: Hehir, Kathleen M, Baguisi, Alexander, Pennington, Sarah E, Bates, Janna M, DiTullio, Paul A
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c394t-5af991d4d4f96dbfac7a506689d30e24738563a2bec1dd2c13ac6ebb8599008b3
cites cdi_FETCH-LOGICAL-c394t-5af991d4d4f96dbfac7a506689d30e24738563a2bec1dd2c13ac6ebb8599008b3
container_end_page 549
container_issue 4
container_start_page 543
container_title Peptides (New York, N.Y. : 1980)
container_volume 25
creator Hehir, Kathleen M
Baguisi, Alexander
Pennington, Sarah E
Bates, Janna M
DiTullio, Paul A
description New therapies in cancer treatment are focusing on multifaceted approaches to starve and kill tumors utilizing both antiangiogenic and chemotherapeutic compounds. Antineoplastic Urinary Protein (ANUP), a 32 kDa protein normally secreted in human urine, has been previously described as a molecule possessing both antiproliferative and antiangiogenic activities. Two synthetic peptides complimentary to the N-terminus of ANUP were designed to test their ability to reproduce these beneficial effects but ultimately to provide a more useful small molecule therapeutic. The results show that the peptides reduced tumor burden by up to 70% in a nude mouse model and demonstrated the ability to inhibit blood vessel formation in a chick chorioallantoic membrane assay (CAM).
doi_str_mv 10.1016/j.peptides.2004.02.003
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71962079</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0196978104000750</els_id><sourcerecordid>71962079</sourcerecordid><originalsourceid>FETCH-LOGICAL-c394t-5af991d4d4f96dbfac7a506689d30e24738563a2bec1dd2c13ac6ebb8599008b3</originalsourceid><addsrcrecordid>eNqFkE1r3DAQhkVJaDZJ_0LwJb3ZHVm2LN26hDQpLPTSnIUsjakWf1WSF_rvK3cdmltOc5hn3nl5CLmjUFCg_MuxmHGOzmIoSoCqgLIAYB_IjoqG5TXl8oLsgEqey0bQK3IdwhESWEnxkVzRBNQNiB152WfzFHGMTveZTiMuw-SzLTyLv9DrGZfoTGbRuxParPPT8A8dcZp7Hdbd4t2o_Z9s9inMjbfkstN9wE_bvCEv3x5_Pjznhx9P3x_2h9wwWcW81p2U1Fa26iS3badNo2vgXEjLAMuqYaLmTJctGmptaSjThmPbilpKANGyG_L5nJv-_l4wRDW4YLDvdeq2BNUkASU0MoH8DBo_heCxU7N3Q2qsKKhVqDqqV6FqFaqgVEloOrzbPiztgPb_2WYwAfcboIPRfef1aFx4w4mGsnJt8PXMYfJxcuhVMA5Hg9Z5NFHZyb3X5S9eKJm7</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71962079</pqid></control><display><type>article</type><title>A potential antitumor peptide therapeutic derived from antineoplastic urinary protein</title><source>ScienceDirect Freedom Collection</source><creator>Hehir, Kathleen M ; Baguisi, Alexander ; Pennington, Sarah E ; Bates, Janna M ; DiTullio, Paul A</creator><creatorcontrib>Hehir, Kathleen M ; Baguisi, Alexander ; Pennington, Sarah E ; Bates, Janna M ; DiTullio, Paul A</creatorcontrib><description>New therapies in cancer treatment are focusing on multifaceted approaches to starve and kill tumors utilizing both antiangiogenic and chemotherapeutic compounds. Antineoplastic Urinary Protein (ANUP), a 32 kDa protein normally secreted in human urine, has been previously described as a molecule possessing both antiproliferative and antiangiogenic activities. Two synthetic peptides complimentary to the N-terminus of ANUP were designed to test their ability to reproduce these beneficial effects but ultimately to provide a more useful small molecule therapeutic. The results show that the peptides reduced tumor burden by up to 70% in a nude mouse model and demonstrated the ability to inhibit blood vessel formation in a chick chorioallantoic membrane assay (CAM).</description><identifier>ISSN: 0196-9781</identifier><identifier>EISSN: 1873-5169</identifier><identifier>DOI: 10.1016/j.peptides.2004.02.003</identifier><identifier>PMID: 15165708</identifier><identifier>CODEN: PPTDD5</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Angiogenesis ; Animals ; Antigens, Ly - administration &amp; dosage ; Antineoplastic urinary protein ; ANUP ; Biological and medical sciences ; CAM ; Chick Embryo ; Cost of Illness ; Female ; Fundamental and applied biological sciences. Psychology ; HeLa Cells ; Humans ; Mice ; Mice, Nude ; Neoplasms, Experimental - blood supply ; Neoplasms, Experimental - drug therapy ; Neovascularization, Pathologic - drug therapy ; Neovascularization, Pathologic - pathology ; Peptides - administration &amp; dosage ; Urokinase-Type Plasminogen Activator - administration &amp; dosage ; Vertebrates: endocrinology</subject><ispartof>Peptides (New York, N.Y. : 1980), 2004-04, Vol.25 (4), p.543-549</ispartof><rights>2004 Elsevier Inc.</rights><rights>2004 INIST-CNRS</rights><rights>Copyright 2004 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c394t-5af991d4d4f96dbfac7a506689d30e24738563a2bec1dd2c13ac6ebb8599008b3</citedby><cites>FETCH-LOGICAL-c394t-5af991d4d4f96dbfac7a506689d30e24738563a2bec1dd2c13ac6ebb8599008b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=15871329$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15165708$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hehir, Kathleen M</creatorcontrib><creatorcontrib>Baguisi, Alexander</creatorcontrib><creatorcontrib>Pennington, Sarah E</creatorcontrib><creatorcontrib>Bates, Janna M</creatorcontrib><creatorcontrib>DiTullio, Paul A</creatorcontrib><title>A potential antitumor peptide therapeutic derived from antineoplastic urinary protein</title><title>Peptides (New York, N.Y. : 1980)</title><addtitle>Peptides</addtitle><description>New therapies in cancer treatment are focusing on multifaceted approaches to starve and kill tumors utilizing both antiangiogenic and chemotherapeutic compounds. Antineoplastic Urinary Protein (ANUP), a 32 kDa protein normally secreted in human urine, has been previously described as a molecule possessing both antiproliferative and antiangiogenic activities. Two synthetic peptides complimentary to the N-terminus of ANUP were designed to test their ability to reproduce these beneficial effects but ultimately to provide a more useful small molecule therapeutic. The results show that the peptides reduced tumor burden by up to 70% in a nude mouse model and demonstrated the ability to inhibit blood vessel formation in a chick chorioallantoic membrane assay (CAM).</description><subject>Angiogenesis</subject><subject>Animals</subject><subject>Antigens, Ly - administration &amp; dosage</subject><subject>Antineoplastic urinary protein</subject><subject>ANUP</subject><subject>Biological and medical sciences</subject><subject>CAM</subject><subject>Chick Embryo</subject><subject>Cost of Illness</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HeLa Cells</subject><subject>Humans</subject><subject>Mice</subject><subject>Mice, Nude</subject><subject>Neoplasms, Experimental - blood supply</subject><subject>Neoplasms, Experimental - drug therapy</subject><subject>Neovascularization, Pathologic - drug therapy</subject><subject>Neovascularization, Pathologic - pathology</subject><subject>Peptides - administration &amp; dosage</subject><subject>Urokinase-Type Plasminogen Activator - administration &amp; dosage</subject><subject>Vertebrates: endocrinology</subject><issn>0196-9781</issn><issn>1873-5169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNqFkE1r3DAQhkVJaDZJ_0LwJb3ZHVm2LN26hDQpLPTSnIUsjakWf1WSF_rvK3cdmltOc5hn3nl5CLmjUFCg_MuxmHGOzmIoSoCqgLIAYB_IjoqG5TXl8oLsgEqey0bQK3IdwhESWEnxkVzRBNQNiB152WfzFHGMTveZTiMuw-SzLTyLv9DrGZfoTGbRuxParPPT8A8dcZp7Hdbd4t2o_Z9s9inMjbfkstN9wE_bvCEv3x5_Pjznhx9P3x_2h9wwWcW81p2U1Fa26iS3badNo2vgXEjLAMuqYaLmTJctGmptaSjThmPbilpKANGyG_L5nJv-_l4wRDW4YLDvdeq2BNUkASU0MoH8DBo_heCxU7N3Q2qsKKhVqDqqV6FqFaqgVEloOrzbPiztgPb_2WYwAfcboIPRfef1aFx4w4mGsnJt8PXMYfJxcuhVMA5Hg9Z5NFHZyb3X5S9eKJm7</recordid><startdate>20040401</startdate><enddate>20040401</enddate><creator>Hehir, Kathleen M</creator><creator>Baguisi, Alexander</creator><creator>Pennington, Sarah E</creator><creator>Bates, Janna M</creator><creator>DiTullio, Paul A</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040401</creationdate><title>A potential antitumor peptide therapeutic derived from antineoplastic urinary protein</title><author>Hehir, Kathleen M ; Baguisi, Alexander ; Pennington, Sarah E ; Bates, Janna M ; DiTullio, Paul A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c394t-5af991d4d4f96dbfac7a506689d30e24738563a2bec1dd2c13ac6ebb8599008b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Angiogenesis</topic><topic>Animals</topic><topic>Antigens, Ly - administration &amp; dosage</topic><topic>Antineoplastic urinary protein</topic><topic>ANUP</topic><topic>Biological and medical sciences</topic><topic>CAM</topic><topic>Chick Embryo</topic><topic>Cost of Illness</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>HeLa Cells</topic><topic>Humans</topic><topic>Mice</topic><topic>Mice, Nude</topic><topic>Neoplasms, Experimental - blood supply</topic><topic>Neoplasms, Experimental - drug therapy</topic><topic>Neovascularization, Pathologic - drug therapy</topic><topic>Neovascularization, Pathologic - pathology</topic><topic>Peptides - administration &amp; dosage</topic><topic>Urokinase-Type Plasminogen Activator - administration &amp; dosage</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hehir, Kathleen M</creatorcontrib><creatorcontrib>Baguisi, Alexander</creatorcontrib><creatorcontrib>Pennington, Sarah E</creatorcontrib><creatorcontrib>Bates, Janna M</creatorcontrib><creatorcontrib>DiTullio, Paul A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Peptides (New York, N.Y. : 1980)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hehir, Kathleen M</au><au>Baguisi, Alexander</au><au>Pennington, Sarah E</au><au>Bates, Janna M</au><au>DiTullio, Paul A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A potential antitumor peptide therapeutic derived from antineoplastic urinary protein</atitle><jtitle>Peptides (New York, N.Y. : 1980)</jtitle><addtitle>Peptides</addtitle><date>2004-04-01</date><risdate>2004</risdate><volume>25</volume><issue>4</issue><spage>543</spage><epage>549</epage><pages>543-549</pages><issn>0196-9781</issn><eissn>1873-5169</eissn><coden>PPTDD5</coden><abstract>New therapies in cancer treatment are focusing on multifaceted approaches to starve and kill tumors utilizing both antiangiogenic and chemotherapeutic compounds. Antineoplastic Urinary Protein (ANUP), a 32 kDa protein normally secreted in human urine, has been previously described as a molecule possessing both antiproliferative and antiangiogenic activities. Two synthetic peptides complimentary to the N-terminus of ANUP were designed to test their ability to reproduce these beneficial effects but ultimately to provide a more useful small molecule therapeutic. The results show that the peptides reduced tumor burden by up to 70% in a nude mouse model and demonstrated the ability to inhibit blood vessel formation in a chick chorioallantoic membrane assay (CAM).</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>15165708</pmid><doi>10.1016/j.peptides.2004.02.003</doi><tpages>7</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0196-9781
ispartof Peptides (New York, N.Y. : 1980), 2004-04, Vol.25 (4), p.543-549
issn 0196-9781
1873-5169
language eng
recordid cdi_proquest_miscellaneous_71962079
source ScienceDirect Freedom Collection
subjects Angiogenesis
Animals
Antigens, Ly - administration & dosage
Antineoplastic urinary protein
ANUP
Biological and medical sciences
CAM
Chick Embryo
Cost of Illness
Female
Fundamental and applied biological sciences. Psychology
HeLa Cells
Humans
Mice
Mice, Nude
Neoplasms, Experimental - blood supply
Neoplasms, Experimental - drug therapy
Neovascularization, Pathologic - drug therapy
Neovascularization, Pathologic - pathology
Peptides - administration & dosage
Urokinase-Type Plasminogen Activator - administration & dosage
Vertebrates: endocrinology
title A potential antitumor peptide therapeutic derived from antineoplastic urinary protein
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T06%3A02%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20potential%20antitumor%20peptide%20therapeutic%20derived%20from%20antineoplastic%20urinary%20protein&rft.jtitle=Peptides%20(New%20York,%20N.Y.%20:%201980)&rft.au=Hehir,%20Kathleen%20M&rft.date=2004-04-01&rft.volume=25&rft.issue=4&rft.spage=543&rft.epage=549&rft.pages=543-549&rft.issn=0196-9781&rft.eissn=1873-5169&rft.coden=PPTDD5&rft_id=info:doi/10.1016/j.peptides.2004.02.003&rft_dat=%3Cproquest_cross%3E71962079%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c394t-5af991d4d4f96dbfac7a506689d30e24738563a2bec1dd2c13ac6ebb8599008b3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=71962079&rft_id=info:pmid/15165708&rfr_iscdi=true