Hemoglobin level is an independent predictor for adverse cardiovascular outcomes in women undergoing Evaluation for chest pain: Results from the National Heart, Lung, and Blood Institute Women's Ischemia Syndrome Evaluation study

This study was designed to investigate the relationship between hemoglobin level (Hgb) and adverse cardiovascular outcomes in women with suspected ischemia. Low Hgb levels correlate with increased cardiovascular morbidity and mortality in patients presenting with acute myocardial infarction (MI) or...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2004-06, Vol.43 (11), p.2009-2014
Main Authors: ARANT, Christopher B, WESSEL, Timothy R, HANDBERG, Eileen, MANKAD, Sunil, PEPINE, Carl J, OLSON, Marian B, MERZ, C. Noel, SOPKO, George, ROGERS, William J, SHARAF, Barry L, REIS, Steven E, SMITH, Karen M, JOHNSON, B. Delia
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Angina Pectoris
Biological and medical sciences
Biomarkers
Cardiology
Cardiology. Vascular system
Cardiovascular disease
Cholesterol
Coronary Angiography
Drug therapy
Female
Follow-Up Studies
Heart attacks
Heart Failure - blood
Heart Failure - diagnostic imaging
Heart Failure - mortality
Heart Failure - pathology
Hemoglobins - metabolism
Humans
Medical sciences
Middle Aged
Mortality
Myocardial Infarction - blood
Myocardial Infarction - diagnostic imaging
Myocardial Infarction - mortality
Myocardial Infarction - pathology
Predictive Value of Tests
Prospective Studies
Studies
Survival Analysis
United States - epidemiology
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Summary:This study was designed to investigate the relationship between hemoglobin level (Hgb) and adverse cardiovascular outcomes in women with suspected ischemia. Low Hgb levels correlate with increased cardiovascular morbidity and mortality in patients presenting with acute myocardial infarction (MI) or congestive heart failure (CHF). However, the prognostic significance of Hgb in women with suspected ischemia is unclear. As part of the National Heart, Lung, and Blood Institute (NHLBI)-sponsored Women's Ischemia Syndrome Evaluation (WISE), we prospectively studied 936 women referred for coronary angiography to evaluate suspected ischemia. We compared Hgb levels with cardiovascular risk factors, core lab interpreted angiograms, inflammatory markers, and adverse cardiovascular outcomes. Of women enrolled, 864 (mean age 58.4 +/-11.6 years) had complete Hgb, angiogram, and follow-up (mean 3.3 +/- 1.7 years) data. The mean Hgb was 12.9 g/dl (range 7.7 to 16.4 g/dl) and 184 women (21%) were anemic (Hgb
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2004.01.038