Loading…
Defining Tympanostomy Tube Plugs
Objectives To define the composition of tympanostomy tube plugs because selecting or developing effective solvents depends on such knowledge. Study Design Prospective, in vitro laboratory study. Methods Luminal contents of 105 plugged, microscopically removed tympanostomy tubes were expressed, poole...
Saved in:
| Published in: | The Laryngoscope 2002-06, Vol.112 (6), p.951-954 |
|---|---|
| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c4403-befbbe036657eb8765752cdc4fecb7fbe608760eedc4005130f0fa890025d143 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c4403-befbbe036657eb8765752cdc4fecb7fbe608760eedc4005130f0fa890025d143 |
| container_end_page | 954 |
| container_issue | 6 |
| container_start_page | 951 |
| container_title | The Laryngoscope |
| container_volume | 112 |
| creator | Westine, John G. Giannoni, Carla M. Antonelli, Patrick J. |
| description | Objectives To define the composition of tympanostomy tube plugs because selecting or developing effective solvents depends on such knowledge.
Study Design Prospective, in vitro laboratory study.
Methods Luminal contents of 105 plugged, microscopically removed tympanostomy tubes were expressed, pooled, acid hydrolyzed, and passed through a high‐performance liquid chromatography column. Retention times were compared with high‐performance liquid chromatography standards to develop free amino acid and monosaccharide profiles. Cerumen, blood, and chronic mucoid effusion (collected during myringotomy) were pooled and subjected to the same analysis. The elution profiles of each substance were compared to determine which substance most closely matched the plugs.
Results High‐performance liquid chromatography amino acid and monosaccharide analysis demonstrated greatest similarity between tympanostomy tube plugs and mucoid effusion.
Conclusions Tympanostomy tube plug composition is more similar to mucoid effusion than to blood or cerumen. Solvents to open plugged tympanostomy tubes should be directed against the components of mucoid effusion. |
| doi_str_mv | 10.1097/00005537-200206000-00003 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71975610</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>71975610</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4403-befbbe036657eb8765752cdc4fecb7fbe608760eedc4005130f0fa890025d143</originalsourceid><addsrcrecordid>eNqNkF9PwjAUxRujEUS_gtmLvk1v13VljwQUjETREFFfmm7ckun-4Mqi-_Z2MvHVvtz09HdPTw4hDoULCqG4BHs4Z8L1ADwI7M1tJLZHupQz6vphyPdJ1z4yt8-95w45MuYNgArG4ZB0qEcD8ELoEmeEOsmTfOXM62yt8sJsiqx25lWEziytVuaYHGiVGjxpZ4_Mr6_mw4k7vR_fDAdTN_Z9YG6EOooQWBBwgVFf2MG9eBn7GuNI6AgDsCIgWslmpww0aNUPbUS-pD7rkfOt7bosPio0G5klJsY0VTkWlZGChoIHFCzY34JxWRhTopbrMslUWUsKsilH_pYjd-X8SMyunrZ_VFGGy7_Ftg0LnLWAMrFKdanyODF_HBOUsSC03GjLfSYp1v8OIKeDxxfOfUobtcnjbm0Ss8GvnY0q32UgmOBycTeWtwsxmT08jeQr-wZhSYxU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71975610</pqid></control><display><type>article</type><title>Defining Tympanostomy Tube Plugs</title><source>Wiley:Jisc Collections:Wiley Read and Publish Open Access 2024-2025 (reading list)</source><creator>Westine, John G. ; Giannoni, Carla M. ; Antonelli, Patrick J.</creator><creatorcontrib>Westine, John G. ; Giannoni, Carla M. ; Antonelli, Patrick J.</creatorcontrib><description>Objectives To define the composition of tympanostomy tube plugs because selecting or developing effective solvents depends on such knowledge.
Study Design Prospective, in vitro laboratory study.
Methods Luminal contents of 105 plugged, microscopically removed tympanostomy tubes were expressed, pooled, acid hydrolyzed, and passed through a high‐performance liquid chromatography column. Retention times were compared with high‐performance liquid chromatography standards to develop free amino acid and monosaccharide profiles. Cerumen, blood, and chronic mucoid effusion (collected during myringotomy) were pooled and subjected to the same analysis. The elution profiles of each substance were compared to determine which substance most closely matched the plugs.
Results High‐performance liquid chromatography amino acid and monosaccharide analysis demonstrated greatest similarity between tympanostomy tube plugs and mucoid effusion.
Conclusions Tympanostomy tube plug composition is more similar to mucoid effusion than to blood or cerumen. Solvents to open plugged tympanostomy tubes should be directed against the components of mucoid effusion.</description><identifier>ISSN: 0023-852X</identifier><identifier>EISSN: 1531-4995</identifier><identifier>DOI: 10.1097/00005537-200206000-00003</identifier><identifier>PMID: 12160290</identifier><identifier>CODEN: LARYA8</identifier><language>eng</language><publisher>Hoboken, NJ: John Wiley & Sons, Inc</publisher><subject>Amino Acids - analysis ; Biological and medical sciences ; Chromatography, High Pressure Liquid ; Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology ; Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics ; Humans ; Medical sciences ; middle ear effusion ; Middle Ear Ventilation ; Monosaccharides - analysis ; mucoid ; Mucus - chemistry ; Non tumoral diseases ; Otitis Media with Effusion - metabolism ; Otorhinolaryngology. Stomatology ; Prospective Studies ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the ear, the auditive nerve and the facial nerve ; Tympanostomy tube</subject><ispartof>The Laryngoscope, 2002-06, Vol.112 (6), p.951-954</ispartof><rights>Copyright © 2002 The Triological Society</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4403-befbbe036657eb8765752cdc4fecb7fbe608760eedc4005130f0fa890025d143</citedby><cites>FETCH-LOGICAL-c4403-befbbe036657eb8765752cdc4fecb7fbe608760eedc4005130f0fa890025d143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,780,784,789,790,23928,23929,25138,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13713369$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12160290$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Westine, John G.</creatorcontrib><creatorcontrib>Giannoni, Carla M.</creatorcontrib><creatorcontrib>Antonelli, Patrick J.</creatorcontrib><title>Defining Tympanostomy Tube Plugs</title><title>The Laryngoscope</title><addtitle>The Laryngoscope</addtitle><description>Objectives To define the composition of tympanostomy tube plugs because selecting or developing effective solvents depends on such knowledge.
Study Design Prospective, in vitro laboratory study.
Methods Luminal contents of 105 plugged, microscopically removed tympanostomy tubes were expressed, pooled, acid hydrolyzed, and passed through a high‐performance liquid chromatography column. Retention times were compared with high‐performance liquid chromatography standards to develop free amino acid and monosaccharide profiles. Cerumen, blood, and chronic mucoid effusion (collected during myringotomy) were pooled and subjected to the same analysis. The elution profiles of each substance were compared to determine which substance most closely matched the plugs.
Results High‐performance liquid chromatography amino acid and monosaccharide analysis demonstrated greatest similarity between tympanostomy tube plugs and mucoid effusion.
Conclusions Tympanostomy tube plug composition is more similar to mucoid effusion than to blood or cerumen. Solvents to open plugged tympanostomy tubes should be directed against the components of mucoid effusion.</description><subject>Amino Acids - analysis</subject><subject>Biological and medical sciences</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology</subject><subject>Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>middle ear effusion</subject><subject>Middle Ear Ventilation</subject><subject>Monosaccharides - analysis</subject><subject>mucoid</subject><subject>Mucus - chemistry</subject><subject>Non tumoral diseases</subject><subject>Otitis Media with Effusion - metabolism</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Prospective Studies</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the ear, the auditive nerve and the facial nerve</subject><subject>Tympanostomy tube</subject><issn>0023-852X</issn><issn>1531-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNqNkF9PwjAUxRujEUS_gtmLvk1v13VljwQUjETREFFfmm7ckun-4Mqi-_Z2MvHVvtz09HdPTw4hDoULCqG4BHs4Z8L1ADwI7M1tJLZHupQz6vphyPdJ1z4yt8-95w45MuYNgArG4ZB0qEcD8ELoEmeEOsmTfOXM62yt8sJsiqx25lWEziytVuaYHGiVGjxpZ4_Mr6_mw4k7vR_fDAdTN_Z9YG6EOooQWBBwgVFf2MG9eBn7GuNI6AgDsCIgWslmpww0aNUPbUS-pD7rkfOt7bosPio0G5klJsY0VTkWlZGChoIHFCzY34JxWRhTopbrMslUWUsKsilH_pYjd-X8SMyunrZ_VFGGy7_Ftg0LnLWAMrFKdanyODF_HBOUsSC03GjLfSYp1v8OIKeDxxfOfUobtcnjbm0Ss8GvnY0q32UgmOBycTeWtwsxmT08jeQr-wZhSYxU</recordid><startdate>200206</startdate><enddate>200206</enddate><creator>Westine, John G.</creator><creator>Giannoni, Carla M.</creator><creator>Antonelli, Patrick J.</creator><general>John Wiley & Sons, Inc</general><general>Wiley-Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>200206</creationdate><title>Defining Tympanostomy Tube Plugs</title><author>Westine, John G. ; Giannoni, Carla M. ; Antonelli, Patrick J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4403-befbbe036657eb8765752cdc4fecb7fbe608760eedc4005130f0fa890025d143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Amino Acids - analysis</topic><topic>Biological and medical sciences</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology</topic><topic>Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>middle ear effusion</topic><topic>Middle Ear Ventilation</topic><topic>Monosaccharides - analysis</topic><topic>mucoid</topic><topic>Mucus - chemistry</topic><topic>Non tumoral diseases</topic><topic>Otitis Media with Effusion - metabolism</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Prospective Studies</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the ear, the auditive nerve and the facial nerve</topic><topic>Tympanostomy tube</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Westine, John G.</creatorcontrib><creatorcontrib>Giannoni, Carla M.</creatorcontrib><creatorcontrib>Antonelli, Patrick J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>The Laryngoscope</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Westine, John G.</au><au>Giannoni, Carla M.</au><au>Antonelli, Patrick J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Defining Tympanostomy Tube Plugs</atitle><jtitle>The Laryngoscope</jtitle><addtitle>The Laryngoscope</addtitle><date>2002-06</date><risdate>2002</risdate><volume>112</volume><issue>6</issue><spage>951</spage><epage>954</epage><pages>951-954</pages><issn>0023-852X</issn><eissn>1531-4995</eissn><coden>LARYA8</coden><abstract>Objectives To define the composition of tympanostomy tube plugs because selecting or developing effective solvents depends on such knowledge.
Study Design Prospective, in vitro laboratory study.
Methods Luminal contents of 105 plugged, microscopically removed tympanostomy tubes were expressed, pooled, acid hydrolyzed, and passed through a high‐performance liquid chromatography column. Retention times were compared with high‐performance liquid chromatography standards to develop free amino acid and monosaccharide profiles. Cerumen, blood, and chronic mucoid effusion (collected during myringotomy) were pooled and subjected to the same analysis. The elution profiles of each substance were compared to determine which substance most closely matched the plugs.
Results High‐performance liquid chromatography amino acid and monosaccharide analysis demonstrated greatest similarity between tympanostomy tube plugs and mucoid effusion.
Conclusions Tympanostomy tube plug composition is more similar to mucoid effusion than to blood or cerumen. Solvents to open plugged tympanostomy tubes should be directed against the components of mucoid effusion.</abstract><cop>Hoboken, NJ</cop><pub>John Wiley & Sons, Inc</pub><pmid>12160290</pmid><doi>10.1097/00005537-200206000-00003</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0023-852X |
| ispartof | The Laryngoscope, 2002-06, Vol.112 (6), p.951-954 |
| issn | 0023-852X 1531-4995 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71975610 |
| source | Wiley:Jisc Collections:Wiley Read and Publish Open Access 2024-2025 (reading list) |
| subjects | Amino Acids - analysis Biological and medical sciences Chromatography, High Pressure Liquid Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics Humans Medical sciences middle ear effusion Middle Ear Ventilation Monosaccharides - analysis mucoid Mucus - chemistry Non tumoral diseases Otitis Media with Effusion - metabolism Otorhinolaryngology. Stomatology Prospective Studies Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the ear, the auditive nerve and the facial nerve Tympanostomy tube |
| title | Defining Tympanostomy Tube Plugs |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T11%3A11%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Defining%20Tympanostomy%20Tube%20Plugs&rft.jtitle=The%20Laryngoscope&rft.au=Westine,%20John%20G.&rft.date=2002-06&rft.volume=112&rft.issue=6&rft.spage=951&rft.epage=954&rft.pages=951-954&rft.issn=0023-852X&rft.eissn=1531-4995&rft.coden=LARYA8&rft_id=info:doi/10.1097/00005537-200206000-00003&rft_dat=%3Cproquest_cross%3E71975610%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c4403-befbbe036657eb8765752cdc4fecb7fbe608760eedc4005130f0fa890025d143%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=71975610&rft_id=info:pmid/12160290&rfr_iscdi=true |