The structure of a biomaterial rather than its chemical composition modulates the repair process at the peritoneal level

Background: This study was designed to establish whether the spatial structure of a prosthesis conditions its behavior at the peritoneal level. Methods: Abdominal defects comprising all the wall (except skin) were created in rabbits and repaired with a laminar (DM) or reticular (CV-4) ePTFE-prosthes...

Full description

Saved in:
Bibliographic Details
Published in:The American journal of surgery 2002-08, Vol.184 (2), p.154-159
Main Authors: Bellón, Juan M, Jurado, Francisca, Garcı́a-Honduvilla, Natalio, López, Raquel, Carrera-San Martı́n, Antonio, Buján, Julia
Format: Article
Language:English
Subjects:
Abdomen
Abdominal Muscles - injuries
Abdominal Muscles - pathology
Abdominal Muscles - surgery
Adhesion
Animals
Behavior
Biocompatible Materials - chemistry
Biological and medical sciences
Biomaterials
Biomedical materials
Chemical composition
Connective tissue
Defects
Disease Models, Animal
Electron microscopes
Fibroblasts
Foreign bodies
Interfaces
Laminar prosthesis
Leukocytes
Light microscopy
Male
Mann-Whitney U test
Materials Testing
Medical sciences
Morphology
Optical microscopy
Peritoneal interface
Peritoneum
Peritoneum - chemistry
Peritoneum - ultrastructure
Probability
Prostheses
Prostheses and Implants
Rabbits
Random Allocation
Reticular prosthesis
Scanning electron microscopy
Sensitivity and Specificity
Statistics, Nonparametric
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the digestive system
Surgical Mesh
Transplants & implants
Wound Healing - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: This study was designed to establish whether the spatial structure of a prosthesis conditions its behavior at the peritoneal level. Methods: Abdominal defects comprising all the wall (except skin) were created in rabbits and repaired with a laminar (DM) or reticular (CV-4) ePTFE-prosthesis. Fourteen days postimplant, specimens were obtained for scanning electron and light microscopy. Peritoneal adhesions, resistance to traction, and neoperitoneum thickness were quantified. Results: Adhesions to CV-4 were firm and integrated within surrounding tissue; only scarce adhesion formation was observed for DM. Adhesion area was significantly greater ( P
ISSN:0002-9610
1879-1883
DOI:10.1016/S0002-9610(02)00907-8